Petersen, K. . (2010). An empirical study of lead-times in incremental and agile software development. In International Conference on Software Process (S. 345–356).
Wiese, J. ., Baumann, H. I., Labes, A. ., Ohlendorf, B. ., Schmaljohann, R. ., Schulz, D. ., … Imhoff, J. F. (2010). New drugs in oncology from marine bacteria and fungi. In AIO-Symposium "Academic Drug Development in Oncology ? Translating Basic Science Research Into Innovative Treatments". Abgerufen von http://oceanrep.geomar.de/10235/
Ferrari, R. ., Madhavji, N. H., Sudmann, O. ., Henke, C. ., Geisler, J. ., & Schafer, W. . (2010). Requirements Engineering Decisions in the Context of an Existing Architecture: A Case Study of a Prototypical Project. In 18th IEEE International Requirements Engineering Conference (S. 79–88). Sydney. http://doi.org/10.1109/RE.2010.19
Schneemann, I. ., Nagel, K. ., Kajahn, I. ., Labes, A. ., Wiese, J. ., & Imhoff, J. F. (2010). Comprehensive Investigation of Marine Actinobacteria Associated with the Sponge Halichondria panicea. Applied and Environmental Microbiology, 76, 3702–3714. Abgerufen von http://oceanrep.geomar.de/8488/
Abstract
Representatives of Actinobacteria were isolated from the marine sponge Halichondria panicea collected from the Baltic Sea (Germany). For the first time, a comprehensive investigation was performed with regard to phylogenetic strain identification, secondary metabolite profiling, bioactivity determination, and genetic exploration of biosynthetic genes, especially concerning the relationships of the abundance of biosynthesis gene fragments to the number and diversity of produced secondary metabolites. All strains were phylogenetically identified by 16S rRNA gene sequence analyses and were found to belong to the genera Actinoalloteichus, Micrococcus, Micromonospora, Nocardiopsis, and Streptomyces. Secondary metabolite profiles of 46 actinobacterial strains were evaluated, 122 different substances were identified, and 88 so far unidentified compounds were detected. The extracts from most of the cultures showed biological activities. In addition, the presence of biosynthesis genes encoding polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) in 30 strains was established. It was shown that strains in which either PKS or NRPS genes were identified produced a significantly higher number of metabolites and exhibited a larger number of unidentified, possibly new metabolites than other strains. Therefore, the presence of PKS and NRPS genes is a good indicator for the selection of strains to isolate new natural products.
Nagel, K. ., Schneemann, I. ., Kajahn, I. ., Wiese, J. ., Labes, A. ., & Imhoff, J. F. (2010). Pseudomonads in association with Saccharina latissima ? evidence of a beneficial interaction in marine environments?. In International VAAM-Workshop "Biology of bacteria producing natural products". Abgerufen von http://oceanrep.geomar.de/10252/
Sondermann-Wölke, C. ., Geisler, J. ., & Sextro, W. . (2010). Increasing the reliability of a self-optimizing railway guidance system. In Proceedings - Annual Reliability and Maintainability Symposium (RAMS) (S. 1–6). San Jose, CA. http://doi.org/10.1109/RAMS.2010.5448080
Schilling, R. ., Brandenburg, M. ., & Kuhn, H. . (2010). Simulation-based Evaluation of Tactical Supply Chain Design Scenarios for New Product Introduction. Porto, Portugal. Abgerufen von http://edoc.ku-eichstaett.de/5102/
Abstract
Based on a case study from the Fast Moving Consumer Goods (FMCG) industry, the paper analyzes and illustrates the simulation-based evaluation of tactical supply chain design (TSCD) scenarios for new product introduction (NPI). The task of TSCD for NPI is to establish product-specific supply chains that cost-efficiently ensure on time and in full availability of new high quality products over the whole product life cycles (PLC). The problem complexity is driven by cross-regional network aspects and inter-disciplinary factors as well as by dynamics and uncertainty in short PLCs. Keywords: Fast Moving Consumer Goods, New Product Introduction, Tactical Supply Chain Design
Labes, A. ., Klotz, H. ., Schneemann, I. ., & Imhoff, J. F. (2010). Efficient screening for secondary metabolites in marine fungi using biosynthetic genes. In CEBITEC Symposium. Abgerufen von http://oceanrep.geomar.de/10245/