Publikationen

2014

Malettinin E, an antibacterial and antifungal tropolone produced by a marine Cladosporium strain

Silber, J. ., Ohlendorf, B. ., Labes, A. ., Wenzel-Storjohann, A. ., Näther, C. ., & Imhoff, J. F. (2014). Malettinin E, an antibacterial and antifungal tropolone produced by a marine Cladosporium strain. Frontiers in Marine Science, 1, 1–6. Abgerufen von http://oceanrep.geomar.de/25470/ (Original work published 2024)

Abstract

The isolation and structure elucidation of malettinins A?C (1?3) along with the new malettinin E (4) are described. The compounds were produced by the fungus Cladosporium sp. strain KF501, which was isolated from the German Wadden Sea. The malettinins are built up of tropolone/dihydropyran ring structures linked to a furan ring. The structure elucidation of the isolated compounds was achieved by means of one- and two-dimensional NMR spectroscopy supported by mass and UV data. The relative configuration of 4 was determined on the basis of single-crystal X-ray diffraction analysis. 1?4 exhibited antibacterial and antifungal activities when profiled against Xanthomonas campestris and Trichophyton rubrum. The influence of the chemical structure of the furan ring and of configurational changes on biological activities was observed.
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2014

Journal Article

Johanna Silber

Birgit Ohlendorf

Antje Labes

Arlette Wenzel-Storjohann

Christian Näther

Johannes Imhoff

marinenaturalproducts

fungalnaturalproducts

antibacterial

antifungal

Cladosporium sp.

malettinin

tropolone
Bioactive metabolites of a marine Calcarisporium sp.

Silber, J. ., Ohlendorf, B. ., Erhard, A. ., Labes, A. ., & Imhoff, J. F. (2014). Bioactive metabolites of a marine Calcarisporium sp. In ELRIG 2014 Research and Innovation - Impact into Cancer. Abgerufen von http://oceanrep.geomar.de/25551/
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2014

Conference Paper

Johanna Silber

Birgit Ohlendorf

Arlette Erhard

Antje Labes

Johannes Imhoff

2013

Calcarides A?E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain

Silber, J. ., Ohlendorf, B. ., Labes, A. ., Erhard, A. ., & Imhoff, J. F. (2013). Calcarides A?E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain. Marine Drugs, 11, 3309–3323. Abgerufen von http://oceanrep.geomar.de/21998/ (Original work published 2024)

Abstract

Bioactive compounds were detected in crude extracts of the fungus, Calcarisporium sp. KF525, which was isolated from German Wadden Sea water samples. Purification of the metabolites from the extracts yielded the five known polyesters, 15G256\ensuremath\alpha, \ensuremath\alpha-2, \ensuremath\beta, \ensuremath\beta-2 and \ensuremath\pi (1?5), and five new derivatives thereof, named calcarides A?E (6?10). The chemical structures of the isolated compounds were elucidated on the basis of one- and two-dimensional NMR spectroscopy supported by UV and HRESIMS data. The compounds exhibited inhibitory activities against Staphylococcus epidermidis, Xanthomonas campestris and Propionibacterium acnes. As the antibacterial activities were highly specific with regard to compound and test strain, a tight structure-activity relationship is assumed.
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2013

Journal Article

Johanna Silber

Birgit Ohlendorf

Antje Labes

Arlette Erhard

Johannes Imhoff

fungal natural products

Calcarisporium sp.

calcarides A?E

15G256 components

macrocyclic and linear polyesters

antibacterial activities

antibiotic

marine natural products
Calcaripeptides A?C, Cyclodepsipeptides from a Calcarisporium Strain

Silber, J. ., Ohlendorf, B. ., Labes, A. ., Näther, C. ., & Imhoff, J. F. (2013). Calcaripeptides A?C, Cyclodepsipeptides from a Calcarisporium Strain. Journal of Natural Products, 76, 1461–1467. Abgerufen von http://oceanrep.geomar.de/21997/ (Original work published Juli 2013)

Abstract

The isolation and structure elucidation of the novel calcaripeptides A (1), B (2), and C (3) and studies on their biosynthetic origin are described. The calcaripeptides were identified from Calcarisporium sp. strain KF525, which was isolated from the German Wadden Sea. Compounds 1?3 are macrocyclic structures composed of a proline and a phenylalanine residue as well as a nonpeptidic substructure. Structure elucidation was achieved by applying one- and two-dimensional NMR spectroscopy supported by high-resolution mass spectrometry. X-ray crystallography was performed to determine the relative configuration of 1. The absolute configuration of 1 was assigned by HPLC of the amino acids after hydrolysis of the molecule and derivatization with chiral agents. Studies on the biosynthesis by feeding 13C-labeled substrates revealed that the nonpeptidic part of 1 originates from acetate and l-methionine. The involvement of a hybrid between a polyketide synthase and a nonribosomal peptide synthetase in the biosynthesis of the calcaripeptides is discussed.
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2013

Journal Article

Johanna Silber

Birgit Ohlendorf

Antje Labes

Christian Näther

Johannes Imhoff

2012

Marine fungi: a rich source for natural products

Silber, J. ., Ohlendorf, B. ., Erhard, A. ., Labes, A. ., & Imhoff, J. F. (2012). Marine fungi: a rich source for natural products. In SUBMARINER Blue Biotechnology Cooperation Event: New Strategies and Future Perspectives. Abgerufen von http://oceanrep.geomar.de/20272/
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2012

Conference Paper

Johanna Silber

Birgit Ohlendorf

Arlette Erhard

Antje Labes

Johannes Imhoff
Secondary metabolites of fungi from the German Wadden Sea

Silber, J. ., Ohlendorf, B. ., Erhard, A. ., Labes, A. ., Goodfellow, M. ., & Imhoff, J. F. (2012). Secondary metabolites of fungi from the German Wadden Sea. In Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie. Abgerufen von http://oceanrep.geomar.de/19556/
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2012

Conference Paper

Johanna Silber

Birgit Ohlendorf

Arlette Erhard

Antje Labes

M. Goodfellow

Johannes Imhoff

2011

Secondary metabolites of fungi associated to the marine sponge Halichondria panacea

Kramer, A. ., Labes, A. ., Wiese, J. ., Ohlendorf, B. ., & Imhoff, J. F. (2011). Secondary metabolites of fungi associated to the marine sponge Halichondria panacea. In MIMAS Symposium. Abgerufen von http://oceanrep.geomar.de/12918/
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2011

Conference Paper

Annemarie Kramer

Antje Labes

Jutta Wiese

Birgit Ohlendorf

Johannes Imhoff

Microbiology

marine sponge Halichondria panacea

2010

Marine Biotechnology: Sustainable uses of marine bacteria and fungi

Wiese, J. ., Baumann, H. I., Kajahn, I. ., Labes, A. ., Ohlendorf, B. ., Schmaljohann, R. ., … Imhoff, J. F. (2010). Marine Biotechnology: Sustainable uses of marine bacteria and fungi. In ESF-COST High Level Research Conference. Abgerufen von http://oceanrep.geomar.de/10246/
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2010

Conference Paper

Jutta Wiese

Heike Baumann

Inga Kajahn

Antje Labes

Birgit Ohlendorf

Rolf Schmaljohann

Dirk Schulz

Rüdiger Stöhr

Heidi Zinecker

Johannes Imhoff

Microbiology

biotechnology

marine fungi

Marine bacteria
New drugs in oncology from marine bacteria and fungi

Wiese, J. ., Baumann, H. I., Labes, A. ., Ohlendorf, B. ., Schmaljohann, R. ., Schulz, D. ., … Imhoff, J. F. (2010). New drugs in oncology from marine bacteria and fungi. In AIO-Symposium "Academic Drug Development in Oncology ? Translating Basic Science Research Into Innovative Treatments". Abgerufen von http://oceanrep.geomar.de/10235/
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2010

Conference Paper

Jutta Wiese

Heike Baumann

Antje Labes

Birgit Ohlendorf

Rolf Schmaljohann

Dirk Schulz

Rüdiger Stöhr

Johannes Imhoff

Microbiology

oncology

Marine bacteria

Fungi

2009

Biological role of secondary metabolites from marine microorganisms

Baumann, H. I., Wiese, J. ., Gärtner, A. ., Goecke, F. R., Heindl, H. ., Kajahn, I. ., … Imhoff, J. F. (2009). Biological role of secondary metabolites from marine microorganisms. VAAM-Symposium "Symbiotische Interaktionen". Abgerufen von http://oceanrep.geomar.de/3859/
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2009

Unpublished

Heike Baumann

Jutta Wiese

Andrea Gärtner

Franz Goecke

Herwig Heindl

Inga Kajahn

Katrin Kleinschmidt

Antje Labes

Kerstin Nagel

Sven Neulinger

Birgit Ohlendorf

Imke Schneemann

Dirk Schulz

Tim Staufenberger

Vera Thiel

Heidi Zinecker

Johannes Imhoff

2014

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