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2014

Bioactive metabolites of a marine Calcarisporium sp.

Silber, J. ., Ohlendorf, B. ., Erhard, A. ., Labes, A. ., & Imhoff, J. F. (2014). Bioactive metabolites of a marine Calcarisporium sp. In ELRIG 2014 Research and Innovation - Impact into Cancer. Abgerufen von http://oceanrep.geomar.de/25551/
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2014

Conference Paper

Johanna Silber

Birgit Ohlendorf

Arlette Erhard

Antje Labes

Johannes Imhoff

2013

Calcarides A?E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain

Silber, J. ., Ohlendorf, B. ., Labes, A. ., Erhard, A. ., & Imhoff, J. F. (2013). Calcarides A?E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain. Marine Drugs, 11, 3309–3323. Abgerufen von http://oceanrep.geomar.de/21998/ (Original work published 2024)

Abstract

Bioactive compounds were detected in crude extracts of the fungus, Calcarisporium sp. KF525, which was isolated from German Wadden Sea water samples. Purification of the metabolites from the extracts yielded the five known polyesters, 15G256\ensuremath\alpha, \ensuremath\alpha-2, \ensuremath\beta, \ensuremath\beta-2 and \ensuremath\pi (1?5), and five new derivatives thereof, named calcarides A?E (6?10). The chemical structures of the isolated compounds were elucidated on the basis of one- and two-dimensional NMR spectroscopy supported by UV and HRESIMS data. The compounds exhibited inhibitory activities against Staphylococcus epidermidis, Xanthomonas campestris and Propionibacterium acnes. As the antibacterial activities were highly specific with regard to compound and test strain, a tight structure-activity relationship is assumed.
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2013

Journal Article

Johanna Silber

Birgit Ohlendorf

Antje Labes

Arlette Erhard

Johannes Imhoff

fungal natural products

Calcarisporium sp.

calcarides A?E

15G256 components

macrocyclic and linear polyesters

antibacterial activities

antibiotic

marine natural products

2012

Marine fungi: a rich source for natural products

Silber, J. ., Ohlendorf, B. ., Erhard, A. ., Labes, A. ., & Imhoff, J. F. (2012). Marine fungi: a rich source for natural products. In SUBMARINER Blue Biotechnology Cooperation Event: New Strategies and Future Perspectives. Abgerufen von http://oceanrep.geomar.de/20272/
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2012

Conference Paper

Johanna Silber

Birgit Ohlendorf

Arlette Erhard

Antje Labes

Johannes Imhoff
Secondary metabolites of fungi from the German Wadden Sea

Silber, J. ., Ohlendorf, B. ., Erhard, A. ., Labes, A. ., Goodfellow, M. ., & Imhoff, J. F. (2012). Secondary metabolites of fungi from the German Wadden Sea. In Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie. Abgerufen von http://oceanrep.geomar.de/19556/
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2012

Conference Paper

Johanna Silber

Birgit Ohlendorf

Arlette Erhard

Antje Labes

M. Goodfellow

Johannes Imhoff

Publikationen

2014

Bioactive metabolites of a marine Calcarisporium sp.

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2013

Calcarides A?E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain

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2012

Marine fungi: a rich source for natural products

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Secondary metabolites of fungi from the German Wadden Sea

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