TY - JOUR
KW - fungal natural products
KW - Calcarisporium sp.
KW - calcarides A?E
KW - 15G256 components
KW - macrocyclic and linear polyesters
KW - antibacterial activities
KW - antibiotic
KW - marine natural products
AU - Johanna Silber
AU - Birgit Ohlendorf
AU - Antje Labes
AU - Arlette Erhard
AU - Johannes Imhoff
AB - Bioactive compounds were detected in crude extracts of the fungus, Calcarisporium sp. KF525, which was isolated from German Wadden Sea water samples. Purification of the metabolites from the extracts yielded the five known polyesters, 15G256\ensuremath\alpha, \ensuremath\alpha-2, \ensuremath\beta, \ensuremath\beta-2 and \ensuremath\pi (1?5), and five new derivatives thereof, named calcarides A?E (6?10). The chemical structures of the isolated compounds were elucidated on the basis of one- and two-dimensional NMR spectroscopy supported by UV and HRESIMS data. The compounds exhibited inhibitory activities against Staphylococcus epidermidis, Xanthomonas campestris and Propionibacterium acnes. As the antibacterial activities were highly specific with regard to compound and test strain, a tight structure-activity relationship is assumed.
BT - Marine Drugs
DA - August
M1 - 9
N1 - WOS:000328621900013
N2 - Bioactive compounds were detected in crude extracts of the fungus, Calcarisporium sp. KF525, which was isolated from German Wadden Sea water samples. Purification of the metabolites from the extracts yielded the five known polyesters, 15G256\ensuremath\alpha, \ensuremath\alpha-2, \ensuremath\beta, \ensuremath\beta-2 and \ensuremath\pi (1?5), and five new derivatives thereof, named calcarides A?E (6?10). The chemical structures of the isolated compounds were elucidated on the basis of one- and two-dimensional NMR spectroscopy supported by UV and HRESIMS data. The compounds exhibited inhibitory activities against Staphylococcus epidermidis, Xanthomonas campestris and Propionibacterium acnes. As the antibacterial activities were highly specific with regard to compound and test strain, a tight structure-activity relationship is assumed.
PY - 2013
SP - 3309
EP - 3323
T2 - Marine Drugs
TI - Calcarides A?E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain
UR - http://oceanrep.geomar.de/21998/
VL - 11
ER -