@article{950,
  author = {Johanna Silber and Birgit Ohlendorf and Antje Labes and Christian Näther and Johannes Imhoff},
  title = {Calcaripeptides A?C, Cyclodepsipeptides from a Calcarisporium Strain},
  abstract = {<p>The isolation and structure elucidation of the novel calcaripeptides A (1), B (2), and C (3) and studies on their biosynthetic origin are described. The calcaripeptides were identified from Calcarisporium sp. strain KF525, which was isolated from the German Wadden Sea. Compounds 1?3 are macrocyclic structures composed of a proline and a phenylalanine residue as well as a nonpeptidic substructure. Structure elucidation was achieved by applying one- and two-dimensional NMR spectroscopy supported by high-resolution mass spectrometry. X-ray crystallography was performed to determine the relative configuration of 1. The absolute configuration of 1 was assigned by HPLC of the amino acids after hydrolysis of the molecule and derivatization with chiral agents. Studies on the biosynthesis by feeding 13C-labeled substrates revealed that the nonpeptidic part of 1 originates from acetate and l-methionine. The involvement of a hybrid between a polyketide synthase and a nonribosomal peptide synthetase in the biosynthesis of the calcaripeptides is discussed.</p>
},
  year = {2013},
  booktitle = {Journal of Natural Products},
  journal = {Journal of Natural Products},
  volume = {76},
  number = {8},
  pages = {1461-1467},
  month = {07/2013},
  url = {http://oceanrep.geomar.de/21997/},
  note = {WOS:000323630500010},
}