Barney, S. ., Khurum, M. ., Petersen, K. ., Unterkalmsteiner, M. ., & Jabangwe, R. . (2011). Improving students with rubric-based self-assessment and oral feedback. IEEE Transactions on Education, 55, 319–325.
Bott, O. ., Dresing, K. ., Wagner, M. ., Raab, B.-W. ., & Teistler, M. . (2011). Informatics in Radiology: Use of a C-Arm Fluoroscopy Simulator to Support Training in Intraoperative Radiography. RadioGraphics, 31, E65-E75. http://doi.org/10.1148/rg.313105125
Imhoff, J. F., Labes, A. ., & Wiese, J. . (2011). Bio-mining the microbial treasures of the ocean: New natural products. Biotechnology Advances, 29, 468–482. Abgerufen von http://oceanrep.geomar.de/12044/
Abstract
The biological resources of the oceans have been exploited since ancient human history, mainly by catching fish and harvesting algae. Research on natural products with special emphasis on marine animals and also algae during the last decades of the 20th century has revealed the importance of marine organisms as producers of substances useful for the treatment of human diseases. Though a large number of bioactive substances have been identified, some many years ago, only recently the first drugs from the oceans were approved. Quite astonishingly, the immense diversity of microbes in the marine environments and their almost untouched capacity to produce natural products and therefore the importance of microbes for marine biotechnology was realized on a broad basis by the scientific communities only recently. This has strengthened worldwide research activities dealing with the exploration of marine microorganisms for biotechnological applications, which comprise the production of bioactive compounds for pharmaceutical use, as well as the development of other valuable products, such as enzymes, nutraceuticals and cosmetics. While the focus in these fields was mainly on marine bacteria, also marine fungi now receive growing attention. Although culture-dependent studies continue to provide interesting new chemical structures with biological activities at a high rate and represent highly promising approaches for the search of new drugs, exploration and use of genomic and metagenomic resources are considered to further increase this potential. Many efforts are made for the sustainable exploration of marine microbial resources. Large culture collections specifically of marine bacteria and marine fungi are available. Compound libraries of marine natural products, even of highly purified substances, were established. The expectations into the commercial exploitation of marine microbial resources has given rise to numerous institutions worldwide, basic research facilities as well as companies. In Europe, recent activities have initiated a dynamic development in marine biotechnology, though concentrated efforts on marine natural product research are rare. One of these activities is represented by the Kieler Wirkstoff-Zentrum KiWiZ, which was founded in 2005 in Kiel (Germany).
Pornak, S. C., Meyer, T. ., & Raspe, H. . (2011). Priorisierung in der Medizin – Verlauf und Ergebnisse der dänischen Priorisierungsdebatte. Das Gesundheitswesen, 73, 680–687.
Faber, P. D.-I. T. ., Hansen, K. ., & Klinke, L. . (2010). Erste Richtlinie für den Weiterbetrieb von Windenergieanlagen veröffentlicht. Erneuerbare Energien, 1. (Original work published Januar 2010)
Schneemann, I. ., Nagel, K. ., Kajahn, I. ., Labes, A. ., Wiese, J. ., & Imhoff, J. F. (2010). Comprehensive Investigation of Marine Actinobacteria Associated with the Sponge Halichondria panicea. Applied and Environmental Microbiology, 76, 3702–3714. Abgerufen von http://oceanrep.geomar.de/8488/
Abstract
Representatives of Actinobacteria were isolated from the marine sponge Halichondria panicea collected from the Baltic Sea (Germany). For the first time, a comprehensive investigation was performed with regard to phylogenetic strain identification, secondary metabolite profiling, bioactivity determination, and genetic exploration of biosynthetic genes, especially concerning the relationships of the abundance of biosynthesis gene fragments to the number and diversity of produced secondary metabolites. All strains were phylogenetically identified by 16S rRNA gene sequence analyses and were found to belong to the genera Actinoalloteichus, Micrococcus, Micromonospora, Nocardiopsis, and Streptomyces. Secondary metabolite profiles of 46 actinobacterial strains were evaluated, 122 different substances were identified, and 88 so far unidentified compounds were detected. The extracts from most of the cultures showed biological activities. In addition, the presence of biosynthesis genes encoding polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) in 30 strains was established. It was shown that strains in which either PKS or NRPS genes were identified produced a significantly higher number of metabolites and exhibited a larger number of unidentified, possibly new metabolites than other strains. Therefore, the presence of PKS and NRPS genes is a good indicator for the selection of strains to isolate new natural products.
Petersen, K. ., & Wohlin, C. . (2010). Software process improvement through the Lean Measurement (SPI-LEAM) method. Journal of Systems and Software, 83, 1275–1287.
Petersen, K. . (2010). Implementing lean and agile software development in industry. Blekinge Institute of Technology Doctoral Dissertation Series, 2010.