Publikationen

2013

• Calcarides A?E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain

  Silber, J. ., Ohlendorf, B. ., Labes, A. ., Erhard, A. ., & Imhoff, J. F. (2013). Calcarides A?E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain. Marine Drugs, 11, 3309–3323. Abgerufen von http://oceanrep.geomar.de/21998/ (Original work published 2025)

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  Bioactive compounds were detected in crude extracts of the fungus, Calcarisporium sp. KF525, which was isolated from German Wadden Sea water samples. Purification of the metabolites from the extracts yielded the five known polyesters, 15G256\ensuremath\alpha, \ensuremath\alpha-2, \ensuremath\beta, \ensuremath\beta-2 and \ensuremath\pi (1?5), and five new derivatives thereof, named calcarides A?E (6?10). The chemical structures of the isolated compounds were elucidated on the basis of one- and two-dimensional NMR spectroscopy supported by UV and HRESIMS data. The compounds exhibited inhibitory activities against Staphylococcus epidermidis, Xanthomonas campestris and Propionibacterium acnes. As the antibacterial activities were highly specific with regard to compound and test strain, a tight structure-activity relationship is assumed.

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  • 2013
  • Journal Article
  • • Johanna Silber
    • Birgit Ohlendorf
    • Antje Labes
    • Arlette Erhard
    • Johannes Imhoff
  • • fungal natural products
    • Calcarisporium sp.
    • calcarides A?E
    • 15G256 components
    • macrocyclic and linear polyesters
    • antibacterial activities
    • antibiotic
    • marine natural products

• FH Flensburg erforscht dynamische Leistungsbereitstellung durch WEA

  Jauch, C. . (2013). FH Flensburg erforscht dynamische Leistungsbereitstellung durch WEA. Ingenieurspiegel, 22. (Original work published November 2013)

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    • Jauch, Clemens

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  • 2013
  • Magazine Article
  • • Prof. Dr. Clemens Jauch
  • • WETI

• Making SMCP count!

  John, P. ., Björkroth, P. ., & Noble, A. . (2013). Making SMCP count!. In International Maritime English Conference (IMLA-IMEC) (S. 15). Istanbul (Turkey): Piri Reis University (Istanbul, Turkey). Abgerufen von http://imla.co/sites/default/files/imec25.pdf (Original work published September 2013)

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  Gustafsson’s (2004)1 linguistic scrutiny of the International Maritime Organization (IMO) Standard Marine Communication Phrases (SMCP) reveals, amongst other characteristics, that almost 900 of the 2,500 so-called “content words” appear only once in the document offering “no support from repetition in the learning task” (ibid. p.179). The accusation that the SMCP are difficult to learn is a criticism often leveled at the phrases. Indeed, teachers of Maritime English frequently struggle to find an optimum means to encourage learning of this particular aspect of the syllabus. The aim of the SMCP is, however, to promote and enhance safety at sea through concise, unambiguous communication and, as a result, knowledge and use of the phrases are required by the IMO Standards of Training, Certification and Watchkeeping (STCW). Such justifiable and laudable motives are, one would think, enough to encourage any cadet “worth his or her salt” to master the SMCP. Experience in many MET institutions proves otherwise however.This paper suggests that classroom “low-fi” simulation of bridge team interaction may be used as an innovative means of encouraging and developing competent use of English, including SMCP, during onboard communication. In December 2012, the first of a proposed series of simulations was conducted at Novia University of Applied Sciences in Finland, Jade University of Applied Sciences in Germany and Antwerp Maritime Academy in Belgium. This paper describes the methodology used for the simulation and then goes on to analyse aspects of the data gathered. Using John’s2 (2013) method of analysis, a system of quantifying the content in utterances is applied to highlight technical language and, in particular, SMCP content words. Questions arising from the communication flows produced may have pedagogical implications: does, for example, increased use of the SMCP result in less ambiguity and ultimately greater communicative precision?

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    • John, Peter

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    • Fachbereich 3: Information und Kommunikation

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  • 2013
  • Conference Paper
  • • Peter John
    • Peter Björkroth
    • Alison Noble
  • • Standard Marine Communication Phrases
    • English for special purposes
    • Low-fi simulation
    • Bridge team communication
    • Quantitative linguistics
    • Content words

• Integrated Therapy Safety Management System

  Podtschaske, B. ., Fuchs, D. ., & Friesdorf, W. . (2013). Integrated Therapy Safety Management System. British Journal of Clinical Pharmacology, 76(Suppl 1), 5–13. http://doi.org/https://doi.org/10.1111/bcp.12155 (Original work published September 2013)

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  The aim is to demonstrate the benefit of the medico-ergonomic approach for the redesign of clinical work systems. Based on the six layer model, a concept for an ‘integrated therapy safety management’ is drafted. This concept could serve as a basis to improve resilience. Methods The concept is developed through a concept-based approach. The state of the art of safety and complexity research in human factors and ergonomics forms the basis. The findings are synthesized to a concept for ‘integrated therapy safety management’. The concept is applied by way of example for the ‘medication process’ to demonstrate its practical implementation. Results The ‘integrated therapy safety management’ is drafted in accordance with the six layer model. This model supports a detailed description of specific work tasks, the corresponding responsibilities and related workflows at different layers by using the concept of ‘bridge managers’. ‘Bridge managers’ anticipate potential errors and monitor the controlled system continuously. If disruptions or disturbances occur, they respond with corrective actions which ensure that no harm results and they initiate preventive measures for future procedures. The concept demonstrates that in a complex work system, the human factor is the key element and final authority to cope with the residual complexity. The expertise of the ‘bridge managers’ and the recursive hierarchical structure results in highly adaptive clinical work systems and increases their resilience. Conclusions The medico-ergonomic approach is a highly promising way of coping with two complexities. It offers a systematic framework for comprehensive analyses of clinical work systems and promotes interdisciplinary collaboration.

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    • Podtschaske, Beatrice

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    • Gesundheit und Life Sciences

  • Fachbereich

    • Fachbereich 4: Wirtschaft

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  • 2013
  • Journal Article
  • • Beatrice Podtschaske
    • Daniela Fuchs
    • Wolfgang Friesdorf
  • • six layer model
    • complexity
    • drug therapy
    • medico-ergonomic
    • resilience
    • workflow

• Certain CM class fields with smaller generators

  Uzunkol, O. ., & Küçüksakallı, Ömer . (2013). Certain CM class fields with smaller generators. Abgerufen von https://arxiv.org/abs/1307.6273 (Original work published Juli 2013)

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    • Uzunkol, Osmanbey

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    • Fachbereich 3: Information und Kommunikation

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  • 2013
  • Miscellaneous
  • • Osmanbey Uzunkol
    • Ömer Küçüksakallı

• Calcaripeptides A?C, Cyclodepsipeptides from a Calcarisporium Strain

  Silber, J. ., Ohlendorf, B. ., Labes, A. ., Näther, C. ., & Imhoff, J. F. (2013). Calcaripeptides A?C, Cyclodepsipeptides from a Calcarisporium Strain. Journal of Natural Products, 76, 1461–1467. Abgerufen von http://oceanrep.geomar.de/21997/ (Original work published Juli 2013)

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  The isolation and structure elucidation of the novel calcaripeptides A (1), B (2), and C (3) and studies on their biosynthetic origin are described. The calcaripeptides were identified from Calcarisporium sp. strain KF525, which was isolated from the German Wadden Sea. Compounds 1?3 are macrocyclic structures composed of a proline and a phenylalanine residue as well as a nonpeptidic substructure. Structure elucidation was achieved by applying one- and two-dimensional NMR spectroscopy supported by high-resolution mass spectrometry. X-ray crystallography was performed to determine the relative configuration of 1. The absolute configuration of 1 was assigned by HPLC of the amino acids after hydrolysis of the molecule and derivatization with chiral agents. Studies on the biosynthesis by feeding 13C-labeled substrates revealed that the nonpeptidic part of 1 originates from acetate and l-methionine. The involvement of a hybrid between a polyketide synthase and a nonribosomal peptide synthetase in the biosynthesis of the calcaripeptides is discussed.

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  • 2013
  • Journal Article
  • • Johanna Silber
    • Birgit Ohlendorf
    • Antje Labes
    • Christian Näther
    • Johannes Imhoff

• Konzeptstudie für Windenergieanlage mit Azimutlager am Turmfuß

  Faber, P. D.-I. T. ., Beye, T. ., & Rudolf, R. . (2013). Konzeptstudie für Windenergieanlage mit Azimutlager am Turmfuß. Bauingenieur, (6), 6. (Original work published Juni 2013)

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    • Faber, Torsten

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  • 2013
  • Journal Article
  • • Prof. Dr.-Ing. Torsten Faber
    • T. Beye
    • R. Rudolf
  • • WETI

• Information density in bridge team communication and miscommunication—a quantitative approach to evaluate maritime communication

  John, P. ., Brooks, B. ., Wand, C. ., & Schriewer, U. . (2013). Information density in bridge team communication and miscommunication—a quantitative approach to evaluate maritime communication. WMU Journal of Maritime Affairs, 12, 16. http://doi.org/https://doi.org/10.1007/s13437-013-0043-8 (Original work published März 2013)

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  The paper presents a method for measuring the information flow in bridge team communication based on an analysis of the voyage data recorder transcript of MV Cosco Busan alliding with a bridge pillar in San Francisco Bay in dense fog. The aim is to assess the efficiency of maritime communication by developing a specific index suitable for evaluating individual and team communication performance. The allision investigated in this paper leads to the conclusion that the information flow in bridge team communication can be measured quantitatively and that a correlation to external situational factors can be demonstrated.

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    • John, Peter

  • Fachbereich

    • Fachbereich 3: Information und Kommunikation

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  • 2013
  • Journal Article
  • • Peter John
    • Benjamin Brooks
    • Christoph Wand
    • Ulf Schriewer
  • • Maritime communication
    • Bridge team communication
    • Voyage data recorder
    • Quantitative linguistics

• A Safe Control Algorithm for Emulating Grid Inertia in Commercial Wind Turbines

  Geisler, J. ., & Schrader, S. . (2013). A Safe Control Algorithm for Emulating Grid Inertia in Commercial Wind Turbines. In European Wind Energy Association Annual Conference and Exhibition 2013 (EWEA 2013). Wien. (Original work published Februar 2013)

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    • Geisler, Jens

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  • 2013
  • Conference Paper
  • • Jens Geisler
    • Stefan Schrader

• Early drug discovery: Models for Entering Pharmaceutical Pipelines

  Labes, A. . (2013). Early drug discovery: Models for Entering Pharmaceutical Pipelines. In 2. Deutsch-Russisches Forum Biotechnologie. Abgerufen von http://oceanrep.geomar.de/23001/

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  • 2013
  • Conference Paper
  • • Antje Labes