Goecke, F. R., Thiel, V. ., Wiese, J. ., Labes, A. ., & Imhoff, J. F. (2013). Algae as important environment for bacteria - phylogenetic relationships among species isolated from algae. Phycologia, 52, 14–24. Abgerufen von http://oceanrep.geomar.de/19593/
Abstract
Bacteria are an inherent part of the biotic environment of algae. Recent investigations revealed that bacterial communities associated with algae were generally highly host specific. Several new bacterial species and genera were isolated from algae, which suggested that algae were an interesting environment for discovery of new bacterial taxa; however, the distribution of the different phylogenetic groups among those isolates remained unclear, and this information could help to explain specific associations. We conducted a phylogenetic study based on 16S rRNA gene sequences available in GenBank, including 101 validly described bacterial species that were isolated from eukaryotic macro- and micro-algae from marine and freshwater environments. These species were distributed among six bacterial phyla, including: Bacteroidetes (42 species), Proteobacteria (36 species), and Firmicutes, Actinobacteria, Verrucomicrobia and Planctomycetes (23 species). Bacterial species and strains that carried out similar metabolic functions were found to colonize similar algal taxa or algal groups. This assumption was supported by information available from bacterial species descriptions: (1) Most of the bacteria described from microalgae grouped into the Roseobacter clade (Alphaproteobacteria), which indicated that members of this group were well adapted for life in close association with phytoplankton; and (2) 32\% of the bacterial species, mainly isolates from macroalgae, were able to decompose macroalgal polysaccharides. Because algal-bacterial association are still under-studied in various algal groups, we expect a great number of new bacterial taxa to be discovered in the future.
Goecke, F. R., Labes, A. ., Wiese, J. ., & Imhoff, J. F. (2013). Phylogenetic analysis and antibiotic activity of bacteria isolated from the surface of two co-occurring macroalgae from the Baltic Sea. European Journal of Phycology, 48, 47–60. Abgerufen von http://oceanrep.geomar.de/19592/
Abstract
Bacteria associated with Fucus vesiculosus and Delesseria sanguinea, two macroalgae from the Kiel Fjord were investigated seasonally over two years by cultivation-based methods. A total of 166 bacterial strains were isolated from the macroalgae, affiliated to seven classes of bacteria (Actinobacteria, Bacilli, Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Cytophagia and Flavobacteria). According to 16S rRNA gene sequence similarities they were arranged in 82 phylotypes of\ensuremath>99.0\% sequence identity. Assuming that chemical factors rule the bacteriamacroalga and bacteriabacteria interactions on algal surfaces, we tested the antibiotic activity of the bacterial isolates not only against a panel of four standard test organisms (Bacillus subtilis, Candida glabrata, Escherichia coli and Staphylococcus lentus) but also four macroalga-associated microorganisms: Algicola bacteriolytica and Pseudoalteromonas elyakovii (macroalgal pathogens), and Bacillus algicola and Formosa algae (strains associated with algal surfaces). Organic extracts of more than 51\% of the isolates from the two macroalgae inhibited the growth of at least one of the tested microorganisms. As much as 46\% and 45\% of the isolates derived from F. vesiculosus and D. sanguinea, respectively, showed antimicrobial activity against the set of macroalga-associated bacteria, compared with 13 and 19\% against a standard set of microorganisms. High antibacterial activity against macroalgal pathogens and bacterial competitors support the assumption that complex chemical interactions shape the relationships of bacteria associated with macroalgae and suggest that these bacteria are a rich source of antimicrobial metabolites.
Labes, A. . (2013). Early drug discovery: Models for Entering Pharmaceutical Pipelines. In 2. Deutsch-Russisches Forum Biotechnologie. Abgerufen von http://oceanrep.geomar.de/23001/
Mäntylä, M. . , V, Khomh, F. ., Adams, B. ., Engström, E. ., & Petersen, K. . (2013). On rapid releases and software testing. In 2013 IEEE International Conference on Software Maintenance (S. 20–29).
Christiansen, J. ., Hanus, M. ., Reck, F. ., & Seidel, D. . (2013). A Semantics for Weakly Encapsulated Search in Functional Logic Programs. In Proceedings of the 15th Symposium on Principles and Practice of Declarative Programming - PPDP 13 (S. 49–60). ACM Press. http://doi.org/10.1145/2505879.2505896
Abstract
Encapsulated search is a key feature of (functional) logic languages. It allows the programmer to access and process different results of a non-deterministic computation within a program. Unfortunately, due to advanced operational features (lazy evaluation, partial values, infinite structures), there is no straightforward definition of the semantics of encapsulated search in functional logic languages. As a consequence, various proposals and implementations are available but a rigorous definition covering all semantical aspects does not exist. In this paper, we analyze the requirements of encapsulated search in a functional logic language like Curry and provide a comprehensive definition that covers weak encapsulation, a modular form of encapsulation, as well as nested applications of search operators. We set up a denotational semantics that distinguishes non-termination and different levels of failures in a computation. The semantics is also the basis of a practical implementation of search operators in the functional logic language Curry.
Uzunkol, O. . (2013). Generalized class invariants with "Thetanullwerte". Turkish Journal of Mathematics, 37, 165–181. http://doi.org/10.3906/mat-1106-4
Labes, A. . (2013). Bio-mining the microbial treasures of the ocean: Early drug discovery and models for entering pharmaceutical pipelines. In SUBMARINER. Abgerufen von http://oceanrep.geomar.de/23002/
Paun, L. ., Kramer, A. ., Labes, A. ., Imhoff, J. F., & Kempken, F. . (2013). Random mutagenesis in filamentous fungi for higher yields of secondary metabolites. In 44. Annual Conference of the German Genetics Society (GfG). Abgerufen von http://oceanrep.geomar.de/22018/