Publikationen

2013

• Meeresschätze heben ? mit angewandter Forschung aus Norddeutschland

  Labes, A., & Claussen, C. (2013). Meeresschätze heben ? mit angewandter Forschung aus Norddeutschland. In Kieler Salon. Abgerufen von http://oceanrep.geomar.de/23005/

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  • Conference Paper
  • • Antje Labes
    • C. Claussen

• Development of a miniaturised screening method for fungal mutants with enhanced production of specific natural compounds

  Kramer, A., Paun, L., Labes, A., Kempken, F., & Imhoff, J. F. (2013). Development of a miniaturised screening method for fungal mutants with enhanced production of specific natural compounds. In VAAM Jahrestagung 2013. Abgerufen von http://oceanrep.geomar.de/22029/

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  • 2013
  • Conference Paper
  • • Annemarie Kramer
    • Linda Paun
    • Antje Labes
    • Frank Kempken
    • Johannes Imhoff

• Algae as important environment for bacteria - phylogenetic relationships among species isolated from algae

  Goecke, F. R., Thiel, V., Wiese, J., Labes, A., & Imhoff, J. F. (2013). Algae as important environment for bacteria - phylogenetic relationships among species isolated from algae. Phycologia, 52, 14–24. Abgerufen von http://oceanrep.geomar.de/19593/

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  Bacteria are an inherent part of the biotic environment of algae. Recent investigations revealed that bacterial communities associated with algae were generally highly host specific. Several new bacterial species and genera were isolated from algae, which suggested that algae were an interesting environment for discovery of new bacterial taxa; however, the distribution of the different phylogenetic groups among those isolates remained unclear, and this information could help to explain specific associations. We conducted a phylogenetic study based on 16S rRNA gene sequences available in GenBank, including 101 validly described bacterial species that were isolated from eukaryotic macro- and micro-algae from marine and freshwater environments. These species were distributed among six bacterial phyla, including: Bacteroidetes (42 species), Proteobacteria (36 species), and Firmicutes, Actinobacteria, Verrucomicrobia and Planctomycetes (23 species). Bacterial species and strains that carried out similar metabolic functions were found to colonize similar algal taxa or algal groups. This assumption was supported by information available from bacterial species descriptions: (1) Most of the bacteria described from microalgae grouped into the Roseobacter clade (Alphaproteobacteria), which indicated that members of this group were well adapted for life in close association with phytoplankton; and (2) 32\% of the bacterial species, mainly isolates from macroalgae, were able to decompose macroalgal polysaccharides. Because algal-bacterial association are still under-studied in various algal groups, we expect a great number of new bacterial taxa to be discovered in the future.

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  • 2013
  • Journal Article
  • • Franz Goecke
    • Vera Thiel
    • Jutta Wiese
    • Antje Labes
    • Johannes Imhoff
  • • Enzyme
    • Macroalgae
    • Microbe-alga
    • Phytoplankton
    • DINOFLAGELLATE GYMNODINIUM-CATENATUM
    • MARINE ROSEOBACTER LINEAGE
    • DISSOLVED ORGANIC-MATTER
    • IN-SITU HYBRIDIZATION
    • EPIPHYTIC BACTERIAL
    • LAMINARIA-JAPONICA
    • GEN. NOV.
    • COMMUNITY COMPOSITION
    • ALEXANDRIUM SPP.
    • BROWN ALGA

• Visualization of Defect Inflow and Resolution Cycles: Before, During and After Transfer

  Jabangwe, R., Petersen, K., & vSmite, D. \. (2013). Visualization of Defect Inflow and Resolution Cycles: Before, During and After Transfer. In 20th Asia-Pacific Software Engineering Conference.

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    • Petersen, Kai

  • Abteilung/Einrichtung

    • FLAIR - Flensburg Artificial Intelligence Research

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  • 2013
  • Conference Paper
  • • Ronald Jabangwe
    • Kai Petersen
    • Darja vSmite

• Phylogenetic analysis and antibiotic activity of bacteria isolated from the surface of two co-occurring macroalgae from the Baltic Sea

  Goecke, F. R., Labes, A., Wiese, J., & Imhoff, J. F. (2013). Phylogenetic analysis and antibiotic activity of bacteria isolated from the surface of two co-occurring macroalgae from the Baltic Sea. European Journal of Phycology, 48, 47–60. Abgerufen von http://oceanrep.geomar.de/19592/

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  Bacteria associated with Fucus vesiculosus and Delesseria sanguinea, two macroalgae from the Kiel Fjord were investigated seasonally over two years by cultivation-based methods. A total of 166 bacterial strains were isolated from the macroalgae, affiliated to seven classes of bacteria (Actinobacteria, Bacilli, Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Cytophagia and Flavobacteria). According to 16S rRNA gene sequence similarities they were arranged in 82 phylotypes of\ensuremath>99.0\% sequence identity. Assuming that chemical factors rule the bacteriamacroalga and bacteriabacteria interactions on algal surfaces, we tested the antibiotic activity of the bacterial isolates not only against a panel of four standard test organisms (Bacillus subtilis, Candida glabrata, Escherichia coli and Staphylococcus lentus) but also four macroalga-associated microorganisms: Algicola bacteriolytica and Pseudoalteromonas elyakovii (macroalgal pathogens), and Bacillus algicola and Formosa algae (strains associated with algal surfaces). Organic extracts of more than 51\% of the isolates from the two macroalgae inhibited the growth of at least one of the tested microorganisms. As much as 46\% and 45\% of the isolates derived from F. vesiculosus and D. sanguinea, respectively, showed antimicrobial activity against the set of macroalga-associated bacteria, compared with 13 and 19\% against a standard set of microorganisms. High antibacterial activity against macroalgal pathogens and bacterial competitors support the assumption that complex chemical interactions shape the relationships of bacteria associated with macroalgae and suggest that these bacteria are a rich source of antimicrobial metabolites.

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  • 2013
  • Journal Article
  • • Franz Goecke
    • Antje Labes
    • Jutta Wiese
    • Johannes Imhoff
  • • antimicrobial activities
    • bacterial cultures
    • chemical associations
    • Delesseria
    • epiphytic bacteria
    • Fucus
    • Kiel
    • macroalgabacteria associations

• Early drug discovery: Models for Entering Pharmaceutical Pipelines

  Labes, A. (2013). Early drug discovery: Models for Entering Pharmaceutical Pipelines. In 2. Deutsch-Russisches Forum Biotechnologie. Abgerufen von http://oceanrep.geomar.de/23001/

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  • • Antje Labes

• Analyzing an automotive testing process with evidence-based software engineering

  Kasoju, A., Petersen, K., & Mäntylä, M. , V. (2013). Analyzing an automotive testing process with evidence-based software engineering. Information and Software Technology, 55, 1237–1259.

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    • Petersen, Kai

  • Abteilung/Einrichtung

    • FLAIR - Flensburg Artificial Intelligence Research

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  • 2013
  • Journal Article
  • • Abhinaya Kasoju
    • Kai Petersen
    • Mika Mäntylä V

• Bio-mining the microbial treasures of the ocean: Early drug discovery and models for entering pharmaceutical pipelines

  Labes, A. (2013). Bio-mining the microbial treasures of the ocean: Early drug discovery and models for entering pharmaceutical pipelines. In SUBMARINER. Abgerufen von http://oceanrep.geomar.de/23002/

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  • • Antje Labes

• Worldviews, Research Methods, and their Relationship to Validity in Empirical Software Engineering Research

  Petersen, K., & Gencel, C. (2013). Worldviews, Research Methods, and their Relationship to Validity in Empirical Software Engineering Research. In The Joint Conference of the 23nd International Workshop on Software Measurement (IWSM) and the 8th International Conference on Software Process and Product Measurement (Mensura).

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    • Petersen, Kai

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    • FLAIR - Flensburg Artificial Intelligence Research

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  • 2013
  • Conference Paper
  • • Kai Petersen
    • Cigdem Gencel

• Random mutagenesis in filamentous fungi for higher yields of secondary metabolites

  Paun, L., Kramer, A., Labes, A., Imhoff, J. F., & Kempken, F. (2013). Random mutagenesis in filamentous fungi for higher yields of secondary metabolites. In 44. Annual Conference of the German Genetics Society (GfG). Abgerufen von http://oceanrep.geomar.de/22018/

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  • 2013
  • Conference Paper
  • • Linda Paun
    • Annemarie Kramer
    • Antje Labes
    • Johannes Imhoff
    • Frank Kempken