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2011

Bio-mining the microbial treasures of the ocean: New natural products

Imhoff, J. F., Labes, A. ., & Wiese, J. . (2011). Bio-mining the microbial treasures of the ocean: New natural products. Biotechnology Advances, 29, 468–482. Abgerufen von http://oceanrep.geomar.de/12044/

Abstract

The biological resources of the oceans have been exploited since ancient human history, mainly by catching fish and harvesting algae. Research on natural products with special emphasis on marine animals and also algae during the last decades of the 20th century has revealed the importance of marine organisms as producers of substances useful for the treatment of human diseases. Though a large number of bioactive substances have been identified, some many years ago, only recently the first drugs from the oceans were approved. Quite astonishingly, the immense diversity of microbes in the marine environments and their almost untouched capacity to produce natural products and therefore the importance of microbes for marine biotechnology was realized on a broad basis by the scientific communities only recently. This has strengthened worldwide research activities dealing with the exploration of marine microorganisms for biotechnological applications, which comprise the production of bioactive compounds for pharmaceutical use, as well as the development of other valuable products, such as enzymes, nutraceuticals and cosmetics. While the focus in these fields was mainly on marine bacteria, also marine fungi now receive growing attention. Although culture-dependent studies continue to provide interesting new chemical structures with biological activities at a high rate and represent highly promising approaches for the search of new drugs, exploration and use of genomic and metagenomic resources are considered to further increase this potential. Many efforts are made for the sustainable exploration of marine microbial resources. Large culture collections specifically of marine bacteria and marine fungi are available. Compound libraries of marine natural products, even of highly purified substances, were established. The expectations into the commercial exploitation of marine microbial resources has given rise to numerous institutions worldwide, basic research facilities as well as companies. In Europe, recent activities have initiated a dynamic development in marine biotechnology, though concentrated efforts on marine natural product research are rare. One of these activities is represented by the Kieler Wirkstoff-Zentrum KiWiZ, which was founded in 2005 in Kiel (Germany).
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2011

Journal Article

Johannes Imhoff

Antje Labes

Jutta Wiese

Microbiology

Marine bacteria

marine fungi

Bioassays

natural products

Microbial interactions

Compound library

Strain collection

Marine biotechnology in Europe

Genetic resources
Priorisierung in der Medizin – Verlauf und Ergebnisse der dänischen Priorisierungsdebatte

Pornak, S. C., Meyer, T. ., & Raspe, H. . (2011). Priorisierung in der Medizin – Verlauf und Ergebnisse der dänischen Priorisierungsdebatte. Das Gesundheitswesen, 73, 680–687.
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Pornak, Shirin Caroline
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2011

Journal Article

Shirin Pornak

Thorsten Meyer

Heiner Raspe

2010

Erste Richtlinie für den Weiterbetrieb von Windenergieanlagen veröffentlicht

Faber, P. D.-I. T. ., Hansen, K. ., & Klinke, L. . (2010). Erste Richtlinie für den Weiterbetrieb von Windenergieanlagen veröffentlicht. Erneuerbare Energien, 1. (Original work published Januar 2010)
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Faber, Torsten
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2010

Journal Article

Prof. Dr.-Ing. Torsten Faber

K. Hansen

L. Klinke
Comprehensive Investigation of Marine Actinobacteria Associated with the Sponge Halichondria panicea

Schneemann, I. ., Nagel, K. ., Kajahn, I. ., Labes, A. ., Wiese, J. ., & Imhoff, J. F. (2010). Comprehensive Investigation of Marine Actinobacteria Associated with the Sponge Halichondria panicea. Applied and Environmental Microbiology, 76, 3702–3714. Abgerufen von http://oceanrep.geomar.de/8488/

Abstract

Representatives of Actinobacteria were isolated from the marine sponge Halichondria panicea collected from the Baltic Sea (Germany). For the first time, a comprehensive investigation was performed with regard to phylogenetic strain identification, secondary metabolite profiling, bioactivity determination, and genetic exploration of biosynthetic genes, especially concerning the relationships of the abundance of biosynthesis gene fragments to the number and diversity of produced secondary metabolites. All strains were phylogenetically identified by 16S rRNA gene sequence analyses and were found to belong to the genera Actinoalloteichus, Micrococcus, Micromonospora, Nocardiopsis, and Streptomyces. Secondary metabolite profiles of 46 actinobacterial strains were evaluated, 122 different substances were identified, and 88 so far unidentified compounds were detected. The extracts from most of the cultures showed biological activities. In addition, the presence of biosynthesis genes encoding polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) in 30 strains was established. It was shown that strains in which either PKS or NRPS genes were identified produced a significantly higher number of metabolites and exhibited a larger number of unidentified, possibly new metabolites than other strains. Therefore, the presence of PKS and NRPS genes is a good indicator for the selection of strains to isolate new natural products.
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2010

Journal Article

Imke Schneemann

Kerstin Nagel

Inga Kajahn

Antje Labes

Jutta Wiese

Johannes Imhoff

Microbiology

Biology

BIOSYNTHESIS GENE-CLUSTER

COMPLETE GENOME SEQUENCE

STREPTOMYCES SP

BIOLOGICAL PROPERTIES

POLYKETIDE SYNTHASE

NATURAL-PRODUCTS

PSEUDOCERATINA-CLAVATA

ANTIMYCIN ANTIBIOTICS

STRUCTURE ELUCIDATION

CHONDRILLA-NUCULA
First guideline for the continued operation of wind turbines

Faber, P. D.-I. T. ., & Hansen, K. . (2010). First guideline for the continued operation of wind turbines. Steel Construction, 3, 4.
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Faber, Torsten
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2010

Journal Article

Prof. Dr.-Ing. Torsten Faber

K. Hansen
Software process improvement through the Lean Measurement (SPI-LEAM) method

Petersen, K. ., & Wohlin, C. . (2010). Software process improvement through the Lean Measurement (SPI-LEAM) method. Journal of Systems and Software, 83, 1275–1287.
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Petersen, Kai

Abteilung/Einrichtung

FLAIR - Flensburg Artificial Intelligence Research
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2010

Journal Article

Kai Petersen

Claes Wohlin
Implementing lean and agile software development in industry

Petersen, K. . (2010). Implementing lean and agile software development in industry. Blekinge Institute of Technology Doctoral Dissertation Series, 2010.
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Petersen, Kai

Abteilung/Einrichtung

FLAIR - Flensburg Artificial Intelligence Research
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2010

Journal Article

Kai Petersen
Chemical interactions between marine macroalgae and bacteria

Goecke, F. R., Labes, A. ., Wiese, J. ., & Imhoff, J. F. (2010). Chemical interactions between marine macroalgae and bacteria. Marine Ecology Progress Series, 409, 267–299. Abgerufen von http://oceanrep.geomar.de/8734/

Abstract

We review research from the last 40 yr on macroalgal?bacterial interactions. Marine macroalgae have been challenged throughout their evolution by microorganisms and have developed in a world of microbes. Therefore, it is not surprising that a complex array of interactions has evolved between macroalgae and bacteria which basically depends on chemical interactions of various kinds. Bacteria specifically associate with particular macroalgal species and even to certain parts of the algal body. Although the mechanisms of this specificity have not yet been fully elucidated, ecological functions have been demonstrated for some of the associations. Though some of the chemical response mechanisms can be clearly attributed to either the alga or to its epibiont, in many cases the producers as well as the mechanisms triggering the biosynthesis of the biologically active compounds remain ambiguous. Positive macroalgal?bacterial interactions include phytohormone production, morphogenesis of macroalgae triggered by bacterial products, specific antibiotic activities affecting epibionts and elicitation of oxidative burst mechanisms. Some bacteria are able to prevent biofouling or pathogen invasion, or extend the defense mechanisms of the macroalgae itself. Deleterious macroalgal?bacterial interactions induce or generate algal diseases. To inhibit settlement, growth and biofilm formation by bacteria, macroalgae influence bacterial metabolism and quorum sensing, and produce antibiotic compounds. There is a strong need to investigate the bacterial communities living on different coexisting macroalgae using new technologies, but also to investigate the production, localization and secretion of the biological active metabolites involved in those possible ecological interactions.
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2010

Journal Article

Franz Goecke

Antje Labes

Jutta Wiese

Johannes Imhoff

Microbiology

Marine microoganisms

Defense

Beneficial communication

Biofilms

Oxidative burst

Antibiotic activity

Quorum sensing control

GREEN-ALGA ULVA

GRACILARIA-CONFERTA RHODOPHYTA

MAKONBU LAMINARIA-JAPONICA

ICE-ICE DISEASE

KAPPAPHYCUS-ALVAREZII GIGARTINALES

PRIONITIS-LANCEOLATA RHODOPHYTA

SEAWEED SECONDARY METABOLITES

CHONDRUS-CRISPUS RHODOPHYTA

CROSS-SPECIES INDUCTION

GRAM-NEGATIVE BACTERIA
The effect of moving from a plan-driven to an incremental software development approach with agile practices

Petersen, K. ., & Wohlin, C. . (2010). The effect of moving from a plan-driven to an incremental software development approach with agile practices. Empirical Software Engineering, 15, 654–693.
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Petersen, Kai

Abteilung/Einrichtung

FLAIR - Flensburg Artificial Intelligence Research
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2010

Journal Article

Kai Petersen

Claes Wohlin

2009

Autonomous Optimization of UWB Link Access

Pérez-Guirao, M. D., Lübben, R. ., & Kaiser, T. . (2009). Autonomous Optimization of UWB Link Access. Frequenz, 63, 196–199. http://doi.org/10.1515/FREQ.2009.63.9-10.196 (Original work published 2025)
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Lübben, Ralf

Fachbereich

Fachbereich 4: Wirtschaft
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2009

Journal Article

M. Pérez-Guirao

Ralf Lübben

T. Kaiser

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