Publikationen

2014

• Mit der Kraft des Meeres gegen Krebs

  Lange, B. ., & Labes, A. . (2014). Mit der Kraft des Meeres gegen Krebs. Meer Und Küste, 5. Abgerufen von http://oceanrep.geomar.de/25497/ (Original work published 2024)

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  Für die Behandlung schwerer Erkrankungen wie Krebs und entzündlicher Leiden gibt es dringenden Bedarf an neuen Substanzen für effizientere und schonenderer Therapien mit weniger Nebenwirkungen

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  • 2014
  • Journal Article
  • • Beate Lange
    • Antje Labes

• Flatness-based feedforward control of wind turbines using lidar

  Schlipf, D. ., & Cheng, P. W. (2014). Flatness-based feedforward control of wind turbines using lidar. In World Congress of the International Federation of Automatic Control (Bd. 47, S. 5820–5825). Cape Town, South Africa. http://doi.org/10.3182/20140824-6-za-1003.00443 (Original work published 2024)

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    • Schlipf, David

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  • 2014
  • Conference Paper
  • • David Schlipf
    • Po Cheng

• A Phenotypic Screening Approach to Identify Anticancer Compounds Derived from Marine Fungi

  Ellinger, B. ., Silber, J. ., Prashar, A. ., Landskron, J. ., Weber, J. ., Rehermann, S. ., … Imhoff, J. F. (2014). A Phenotypic Screening Approach to Identify Anticancer Compounds Derived from Marine Fungi. ASSAY and Drug Development Technologies, 12, 162–175. Abgerufen von http://oceanrep.geomar.de/24658/ (Original work published 2024)

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  This study covers the isolation, testing, and identification of natural products with anticancer properties. Secondary metabolites were isolated from fungal strains originating from a variety of marine habitats. Strain culture protocols were optimized with respect to growth media composition and fermentation conditions. From these producers, isolated compounds were screened for their effect on the viability and proliferation of a subset of the NCI60 panel of cancer cell lines. Active compounds of interest were identified and selected for detailed assessments and structural elucidation using nuclear magnetic resonance. This revealed the majority of fungal-derived compounds represented known anticancer chemotypes, confirming the integrity of the process and the ability to identify suitable compounds. Examination of effects of selected compounds on cancer-associated cell signaling pathways used phospho flow cytometry in combination with 3D fluorescent cell barcoding. In parallel, the study addressed the logistical aspects of maintaining multiple cancer cell lines in culture simultaneously. A potential solution involving microbead-based cell culture was investigated (BioLevitator, Hamilton). Selected cell lines were cultured in microbead and 2D methods and cell viability tests showed comparable compound inhibition in both methods (R-2=0.95). In a further technology assessment, an image-based assay system was investigated for its utility as a possible complement to ATP-based detection for quantifying cell growth and viability in a label-free manner.

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  • 2014
  • Journal Article
  • • Bernhard Ellinger
    • Johanna Silber
    • Anjali Prashar
    • Johannes Landskron
    • Jonas Weber
    • Sarah Rehermann
    • Franz-Josef Müller
    • Stephen Smith
    • Stephen Wrigley
    • Kjetil en
    • Philip Gribbon
    • Antje Labes
    • Johannes Imhoff
  • • marine fungi
    • natural products
    • cancer
    • pharmacology
    • leukemia

• Lingua Franca and its Grammar Footprint: Introducing an Index for Quantifying Grammatical Diversity in Written and Spoken Language

  John, P. ., & Brooks, B. . (2014). Lingua Franca and its Grammar Footprint: Introducing an Index for Quantifying Grammatical Diversity in Written and Spoken Language. Journal of Quantitative Linguistics, 21(1), 23. http://doi.org/https://doi.org/10.1080/09296174.2013.856130 (Original work published Dezember 2013)

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  The paper introduces a method to quantify grammar diversity based on part-of-speech tagging (POS) and presents a POS diversity index which can be used for analysing written and spoken communication independently of a text’s length. For this purpose, a series of transcripts of the radio programme Lingua Franca, broadcast by the Australian Broadcast Corporation, are assessed. The radio presenter’s grammatical footprint is compared with the POS index values of the invited guests, and the hypothesis that a significant difference in the grammar structures used by the different speakers is tested for validity using a standard ANOVA calculation. Significantly different POS diversity is found in a comparison between groups of speakers. The index provides for comparative studies of grammar structures used by individual speakers or authors.

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    • John, Peter

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    • Fachbereich 3: Information und Kommunikation

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  • 2014
  • Journal Article
  • • Peter John
    • Benjamin Brooks

• Integrating machine translation (MT) in the higher education of translators and technical writers.

  Wittkowsky, M. . (2014). Integrating machine translation (MT) in the higher education of translators and technical writers. In Translating and the Computer 36 (S. 9). London. Abgerufen von https://web.archive.org/web/20200721094751/http://www.mt-archive.info/10/Asling-2014-Wittkowsky.pdf (Original work published November 2014)

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  This paper describes how MT is integrated into a course project for translation and technical writing students. The course project is based on the idea of combining controlled language and a pre-editing step in order to achieve an effective way to prepare contemporary technical documentation for rule-based machine translation (RBMT). I will explain what I mean by “contemporary” within the context of technical documentation and why this attribute plays an important role within the decision-making process to integrate CL, pre-editing and MT in the course project, which also includes practical exercises for the students. In addition, the reason why RBMT is the MT method chosen within the context of multilingual text production is explained.

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    • Wittkowsky, Marion

  • Abteilung/Einrichtung

    • CIVU – Center for Interaction, Visualization and Usability

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    • Fachbereich 3: Information und Kommunikation

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  • 2014
  • Conference Paper
  • • Marion Wittkowsky

• FH Flensburg erforscht dynamische Netzfrequenzstützungdurch Windenergieanlagen

  Jauch, C. ., & Haberl, A. . (2014). FH Flensburg erforscht dynamische Netzfrequenzstützungdurch Windenergieanlagen. Ingenieurspiegel , 4, 2. (Original work published November 2014)

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    • Jauch, Clemens

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  • 2014
  • Magazine Article
  • • Prof. Dr. Clemens Jauch
    • A. Haberl
  • • WETI

• Windenergieanlagen mit verbesserter Leistungsreservenbereithaltung DE102013203540

  Geisler, J. ., Schrader, S. ., Bluhm, R. ., & Petsche, M. . (2014). Windenergieanlagen mit verbesserter Leistungsreservenbereithaltung DE102013203540. Germany: Senvion GmbH. (Original work published 2014)

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    • Geisler, Jens

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  • 2014
  • Patent
  • • Jens Geisler
    • Stefan Schrader
    • R. Bluhm
    • M. Petsche

• Exploiting the didactic possibilities of low-fi simulation in virtual bridge-team communication exercises

  Noble, A. ., Björkroth, P. ., & John, P. . (2014). Exploiting the didactic possibilities of low-fi simulation in virtual bridge-team communication exercises. In International Maritime English Conference (IMLA-IMEC) (S. 16). Terschelling (The Netherlands): Maritime Institute Willem Barentsz . Abgerufen von https://www.pfri.uniri.hr/bopri/IMEC_Proceedings/PDF/IMEC26.pdf (Original work published Juli 2014)

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  The research paper is the second in a series of studies on an improved use of the Standard Marine Communication Phrases (SMCP) during an international low-fi simulation exercise in a classroom setting. Following a briefing on the use of relevant SMCP by means of an e-learning platform, students of Maritime English at several maritime universities participated in a virtual bridge team exercise. The communication patterns employed in their situational assessment and decision making were compared to previous low-fi simulations whereby participants had not received any briefing on the use of SMCP prior to the exercise [1] (cf. John et al., 2013). Based on the different features observed in both exercise settings, the scope for using a constructivist learning environment as offered by low-fi simulations is discussed and possibilities for an integral pedagogical approach towards teaching standard phraseology are outlined.

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    • John, Peter

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    • Fachbereich 3: Information und Kommunikation

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  • 2014
  • Conference Paper
  • • Alison Noble
    • Peter Björkroth
    • Peter John
  • • Bridge team communication
    • Low-fi simulation
    • Standard Marine Communication Phrases
    • Integral pedagogical approach

• Development and Validation of a Fast and Optimized Screening Method for Enhanced Production of Secondary Metabolites Using the Marine Scopulariopsis brevicaulis Strain LF580 Producing Anti-Cancer Active Scopularide A and B

  Kramer, A. ., Paun, L. ., Imhoff, J. F., Kempken, F. ., & Labes, A. . (2014). Development and Validation of a Fast and Optimized Screening Method for Enhanced Production of Secondary Metabolites Using the Marine Scopulariopsis brevicaulis Strain LF580 Producing Anti-Cancer Active Scopularide A and B. PLoS ONE, 9, e103320. Abgerufen von http://oceanrep.geomar.de/25471/ (Original work published Juli 2014)

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  Natural compounds from marine fungi are an excellent source for the discovery and development of new drug leads. The distinct activity profiles of the two cyclodepsipeptides scopularide A and B against cancer cell lines set their marine producer strain Scopulariopsis brevicaulis LF580 into the focus of the EU project MARINE FUNGI. One of the main goals was the development of a sustainable biotechnological production process for these compounds. The secondary metabolite production of strain LF580 was optimized by random mutagenesis employing UV radiation. For a fast and reliable detection of the intracellular secondary metabolite production level, a miniaturized bioactivity-independent screening method was developed, as the random mutagenesis yielded a large number of mutants to be analysed quantitatively and none of the existing hyphenated bioassay-dependent screening systems could be applied. The method includes decreased cultivation volume, a fast extraction procedure as well as an optimized LC-MS analysis. We show that deviation could be specifically reduced at each step of the process: The measuring deviation during the analysis could be minimized to 5\% and technical deviation occurring in the downstream part to 10?15\%. Biological variation during the cultivation process still has the major influence on the overall variation. However, the approach led to a 10-fold reduction of time and similar effects on costs and effort compared to standard reference screening methods. The method was applied to screen the UV-mutants library of Scopulariopsis brevicaulis LF580. For validation purposes, the occurring variations in the miniaturized scale were compared to those in the classical Erlenmeyer flask scale. This proof of concept was performed using the wild type strain and 23 randomly selected mutant strains. One specific mutant strain with an enhanced production behavior could be obtained.

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  • 2014
  • Journal Article
  • • Annemarie Kramer
    • Linda Paun
    • Johannes Imhoff
    • Frank Kempken
    • Antje Labes
  • • Drug metabolism
    • Fungi
    • Library screening
    • Linear regression analysis
    • Liquid chromatography-mass spectrometry
    • Mutant strains Secondary metabolism
    • Ultraviolet radiation

• Windenergieanlage und Verfahren zum Regeln des elektrischen Moments einer Windenergieanlage bei einem Netzfehler DE102012224067

  Geisler, J. ., Schrader, S. ., & Fortmann, J. . (2014). Windenergieanlage und Verfahren zum Regeln des elektrischen Moments einer Windenergieanlage bei einem Netzfehler DE102012224067. Germany: Senvion GmbH. (Original work published Juni 2014)

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    • Geisler, Jens

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  • 2014
  • Patent
  • • Jens Geisler
    • Stefan Schrader
    • J. Fortmann