Imhoff, J. F., Labes, A., & Wiese, J. (2011). Bio-mining the microbial treasures of the ocean: New natural products. Biotechnology Advances, 29, 468–482. Abgerufen von http://oceanrep.geomar.de/12044/
Abstract
The biological resources of the oceans have been exploited since ancient human history, mainly by catching fish and harvesting algae. Research on natural products with special emphasis on marine animals and also algae during the last decades of the 20th century has revealed the importance of marine organisms as producers of substances useful for the treatment of human diseases. Though a large number of bioactive substances have been identified, some many years ago, only recently the first drugs from the oceans were approved. Quite astonishingly, the immense diversity of microbes in the marine environments and their almost untouched capacity to produce natural products and therefore the importance of microbes for marine biotechnology was realized on a broad basis by the scientific communities only recently. This has strengthened worldwide research activities dealing with the exploration of marine microorganisms for biotechnological applications, which comprise the production of bioactive compounds for pharmaceutical use, as well as the development of other valuable products, such as enzymes, nutraceuticals and cosmetics. While the focus in these fields was mainly on marine bacteria, also marine fungi now receive growing attention. Although culture-dependent studies continue to provide interesting new chemical structures with biological activities at a high rate and represent highly promising approaches for the search of new drugs, exploration and use of genomic and metagenomic resources are considered to further increase this potential. Many efforts are made for the sustainable exploration of marine microbial resources. Large culture collections specifically of marine bacteria and marine fungi are available. Compound libraries of marine natural products, even of highly purified substances, were established. The expectations into the commercial exploitation of marine microbial resources has given rise to numerous institutions worldwide, basic research facilities as well as companies. In Europe, recent activities have initiated a dynamic development in marine biotechnology, though concentrated efforts on marine natural product research are rare. One of these activities is represented by the Kieler Wirkstoff-Zentrum KiWiZ, which was founded in 2005 in Kiel (Germany).
Glende, S., Nedopil, C., Podtschaske, B., Stahl, M., & Friesdorf, W. (2011). Erfolgreiche Lösungen durch Nutzerintegration. Ergebnisse der Studie “Nutzerabhängige Innovationsbarrieren im Bereich Altersgerechter Assistenzsysteme”. Berlin, Offenbach: VDE Verlag.
Kramer, A., Labes, A., Wiese, J., Ohlendorf, B., & Imhoff, J. F. (2011). Secondary metabolites of fungi associated to the marine sponge Halichondria panacea. In MIMAS Symposium. Abgerufen von http://oceanrep.geomar.de/12918/
Wiese, J., Schulz, D., Stöhr, R., Nagel, K., Labes, A., Schneemann, I., … Imhoff, J. F. (2011). Biologically active compounds from microorganisms derived from marine macroorganisms and marine sediments. In NatPharma: Nature Aided Drug Discovery, NADD. Abgerufen von http://oceanrep.geomar.de/12921/
Podtschaske, B., Fuchs, D., Gärtner, J., & Friesdorf, W. (2011). Die Notaufnahme aus Patientensicht: Bedürfnisse und Erfahrungen - Ergebnisse aus der Studie Berlin & seine Notaufnahmen . In H. Moecke, C. K. Lackner, & T. Klöss (Hrsg.), Das ZNA-Buch. Konzepte, Methoden, Praxis. (1. Aufl., S. 636). Berlin: MWV Medizinisch Wissenschaftliche Verlagsgesellschaft.
Christiansen, J., & Seidel, D. (2011). Minimally Strict Polymorphic Functions. In Proceedings of the 13th International ACM SIGPLAN Symposium on Principles and Practices of Declarative Programming - PPDP 11 (S. 53). ACM Press. http://doi.org/10.1145/2003476.2003487
Abstract
In this paper we show how to efficiently check whether a polymorphic function is minimally strict. A function is minimally strict if it is the minimal element of a specific less-strict ordering. We prove that we can check whether two polymorphic functions are related by the less-strict ordering by either checking it a) for an arbitrary monomorphic instance of the functions or b) for all shapes of the functions’ argument type. A shape is a value of a monomorphic instance of a polymorphic data type where each polymorphic component is replaced by an element that identifies its position in the data structure. In contrast to recent publications that characterize polymorphic functions by monomorphic instances we consider non-termination and selective strictness, i.e., a language closer to Haskell.
Sundmark, D., Petersen, K., & Larsson, S. (2011). An exploratory case study of testing in an automotive electrical system release process. In 2011 6th IEEE International Symposium on Industrial and Embedded Systems (S. 166–175).
Bischoff, O., Hofsäß, M., Rettenmeier, A., Schlipf, D., & Siegmeier, B. (2010). Statistical load estimation using a nacelle-based lidar system. In German Wind Energy Conference (DEWEK). Bremen, Germany. http://doi.org/10.18419/opus-8730 (Original work published 2025)
Trujillo, J. J., Bischoff, O., Hofsäß, M., Rettenmeier, A., Schlipf, D., & Kühn, M. (2010). Validation of a dynamic meandering model with near wake lidar measurements. In German Wind Energy Conference (DEWEK). Bremen, Germany. Abgerufen von http://oops.uni-oldenburg.de/1834/ (Original work published 2025)