Publikationen

2013

• Calcarides A?E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain

  Silber, J., Ohlendorf, B., Labes, A., Erhard, A., & Imhoff, J. F. (2013). Calcarides A?E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain. Marine Drugs, 11, 3309–3323. Abgerufen von http://oceanrep.geomar.de/21998/ (Original work published 2026)

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  Bioactive compounds were detected in crude extracts of the fungus, Calcarisporium sp. KF525, which was isolated from German Wadden Sea water samples. Purification of the metabolites from the extracts yielded the five known polyesters, 15G256\ensuremath\alpha, \ensuremath\alpha-2, \ensuremath\beta, \ensuremath\beta-2 and \ensuremath\pi (1?5), and five new derivatives thereof, named calcarides A?E (6?10). The chemical structures of the isolated compounds were elucidated on the basis of one- and two-dimensional NMR spectroscopy supported by UV and HRESIMS data. The compounds exhibited inhibitory activities against Staphylococcus epidermidis, Xanthomonas campestris and Propionibacterium acnes. As the antibacterial activities were highly specific with regard to compound and test strain, a tight structure-activity relationship is assumed.

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  • 2013
  • Journal Article
  • • Johanna Silber
    • Birgit Ohlendorf
    • Antje Labes
    • Arlette Erhard
    • Johannes Imhoff
  • • fungal natural products
    • Calcarisporium sp.
    • calcarides A?E
    • 15G256 components
    • macrocyclic and linear polyesters
    • antibacterial activities
    • antibiotic
    • marine natural products

• Integrated Therapy Safety Management System

  Podtschaske, B., Fuchs, D., & Friesdorf, W. (2013). Integrated Therapy Safety Management System. British Journal of Clinical Pharmacology, 76(Suppl 1), 5–13. http://doi.org/https://doi.org/10.1111/bcp.12155 (Original work published September 2013)

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  The aim is to demonstrate the benefit of the medico-ergonomic approach for the redesign of clinical work systems. Based on the six layer model, a concept for an ‘integrated therapy safety management’ is drafted. This concept could serve as a basis to improve resilience. Methods The concept is developed through a concept-based approach. The state of the art of safety and complexity research in human factors and ergonomics forms the basis. The findings are synthesized to a concept for ‘integrated therapy safety management’. The concept is applied by way of example for the ‘medication process’ to demonstrate its practical implementation. Results The ‘integrated therapy safety management’ is drafted in accordance with the six layer model. This model supports a detailed description of specific work tasks, the corresponding responsibilities and related workflows at different layers by using the concept of ‘bridge managers’. ‘Bridge managers’ anticipate potential errors and monitor the controlled system continuously. If disruptions or disturbances occur, they respond with corrective actions which ensure that no harm results and they initiate preventive measures for future procedures. The concept demonstrates that in a complex work system, the human factor is the key element and final authority to cope with the residual complexity. The expertise of the ‘bridge managers’ and the recursive hierarchical structure results in highly adaptive clinical work systems and increases their resilience. Conclusions The medico-ergonomic approach is a highly promising way of coping with two complexities. It offers a systematic framework for comprehensive analyses of clinical work systems and promotes interdisciplinary collaboration.

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    • Podtschaske, Beatrice

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    • Gesundheit und Life Sciences

  • Fachbereich

    • Fachbereich 4: Wirtschaft

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  • 2013
  • Journal Article
  • • Beatrice Podtschaske
    • Daniela Fuchs
    • Wolfgang Friesdorf
  • • six layer model
    • complexity
    • drug therapy
    • medico-ergonomic
    • resilience
    • workflow

• Calcaripeptides A-C, Cyclodepsipeptides from a Calcarisporium Strain

  Silber, J., Ohlendorf, B., Labes, A., Näther, C., & Imhoff, J. F. (2013). Calcaripeptides A-C, Cyclodepsipeptides from a Calcarisporium Strain. Journal of Natural Products, 76, 1461–1467. Abgerufen von http://oceanrep.geomar.de/21997/ (Original work published Juli 2013)

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  The isolation and structure elucidation of the novel calcaripeptides A (1), B (2), and C (3) and studies on their biosynthetic origin are described. The calcaripeptides were identified from Calcarisporium sp. strain KF525, which was isolated from the German Wadden Sea. Compounds 1?3 are macrocyclic structures composed of a proline and a phenylalanine residue as well as a nonpeptidic substructure. Structure elucidation was achieved by applying one- and two-dimensional NMR spectroscopy supported by high-resolution mass spectrometry. X-ray crystallography was performed to determine the relative configuration of 1. The absolute configuration of 1 was assigned by HPLC of the amino acids after hydrolysis of the molecule and derivatization with chiral agents. Studies on the biosynthesis by feeding 13C-labeled substrates revealed that the nonpeptidic part of 1 originates from acetate and l-methionine. The involvement of a hybrid between a polyketide synthase and a nonribosomal peptide synthetase in the biosynthesis of the calcaripeptides is discussed.

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  • Profilbereich

    • Gesundheit und Life Sciences

  • Forschungsfeld

    • Nachhaltige Lebensmittelproduktion und Nutzung der Meere

  • Fachbereich

    • Fachbereich 2: Energy and Life Science

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  • 2013
  • Journal Article
  • • Johanna Silber
    • Birgit Ohlendorf
    • Antje Labes
    • Christian Näther
    • Johannes Imhoff

• Konzeptstudie für Windenergieanlage mit Azimutlager am Turmfuß

  Faber, P. D.-I. T., Beye, T., & Rudolf, R. (2013). Konzeptstudie für Windenergieanlage mit Azimutlager am Turmfuß. Bauingenieur, (6), 6. (Original work published Juni 2013)

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    • Faber, Torsten

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  • 2013
  • Journal Article
  • • Prof. Dr.-Ing. Torsten Faber
    • T. Beye
    • R. Rudolf
  • • WETI

• Information density in bridge team communication and miscommunication—a quantitative approach to evaluate maritime communication

  John, P., Brooks, B., Wand, C., & Schriewer, U. (2013). Information density in bridge team communication and miscommunication—a quantitative approach to evaluate maritime communication. WMU Journal of Maritime Affairs, 12, 16. http://doi.org/https://doi.org/10.1007/s13437-013-0043-8 (Original work published März 2013)

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  The paper presents a method for measuring the information flow in bridge team communication based on an analysis of the voyage data recorder transcript of MV Cosco Busan alliding with a bridge pillar in San Francisco Bay in dense fog. The aim is to assess the efficiency of maritime communication by developing a specific index suitable for evaluating individual and team communication performance. The allision investigated in this paper leads to the conclusion that the information flow in bridge team communication can be measured quantitatively and that a correlation to external situational factors can be demonstrated.

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    • John, Peter

  • Fachbereich

    • Fachbereich 3: Information und Kommunikation

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  • 2013
  • Journal Article
  • • Peter John
    • Benjamin Brooks
    • Christoph Wand
    • Ulf Schriewer
  • • Maritime communication
    • Bridge team communication
    • Voyage data recorder
    • Quantitative linguistics

• Analyzing an automotive testing process with evidence-based software engineering

  Kasoju, A., Petersen, K., & Mäntylä, M. , V. (2013). Analyzing an automotive testing process with evidence-based software engineering. Information and Software Technology, 55, 1237–1259.

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  • Personenseiten

    • Petersen, Kai

  • Abteilung/Einrichtung

    • FLAIR - Flensburg Artificial Intelligence Research

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  • 2013
  • Journal Article
  • • Abhinaya Kasoju
    • Kai Petersen
    • Mika Mäntylä V

• Countermeasure graphs for software security risk assessment: An action research

  Baca, D., & Petersen, K. (2013). Countermeasure graphs for software security risk assessment: An action research. Journal of Systems and Software, 86, 2411–2428.

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    • Petersen, Kai

  • Abteilung/Einrichtung

    • FLAIR - Flensburg Artificial Intelligence Research

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  • 2013
  • Journal Article
  • • Dejan Baca
    • Kai Petersen

• Phylogenetic analysis and antibiotic activity of bacteria isolated from the surface of two co-occurring macroalgae from the Baltic Sea

  Goecke, F. R., Labes, A., Wiese, J., & Imhoff, J. F. (2013). Phylogenetic analysis and antibiotic activity of bacteria isolated from the surface of two co-occurring macroalgae from the Baltic Sea. European Journal of Phycology, 48, 47–60. Abgerufen von http://oceanrep.geomar.de/19592/

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  Bacteria associated with Fucus vesiculosus and Delesseria sanguinea, two macroalgae from the Kiel Fjord were investigated seasonally over two years by cultivation-based methods. A total of 166 bacterial strains were isolated from the macroalgae, affiliated to seven classes of bacteria (Actinobacteria, Bacilli, Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Cytophagia and Flavobacteria). According to 16S rRNA gene sequence similarities they were arranged in 82 phylotypes of\ensuremath>99.0\% sequence identity. Assuming that chemical factors rule the bacteriamacroalga and bacteriabacteria interactions on algal surfaces, we tested the antibiotic activity of the bacterial isolates not only against a panel of four standard test organisms (Bacillus subtilis, Candida glabrata, Escherichia coli and Staphylococcus lentus) but also four macroalga-associated microorganisms: Algicola bacteriolytica and Pseudoalteromonas elyakovii (macroalgal pathogens), and Bacillus algicola and Formosa algae (strains associated with algal surfaces). Organic extracts of more than 51\% of the isolates from the two macroalgae inhibited the growth of at least one of the tested microorganisms. As much as 46\% and 45\% of the isolates derived from F. vesiculosus and D. sanguinea, respectively, showed antimicrobial activity against the set of macroalga-associated bacteria, compared with 13 and 19\% against a standard set of microorganisms. High antibacterial activity against macroalgal pathogens and bacterial competitors support the assumption that complex chemical interactions shape the relationships of bacteria associated with macroalgae and suggest that these bacteria are a rich source of antimicrobial metabolites.

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  • 2013
  • Journal Article
  • • Franz Goecke
    • Antje Labes
    • Jutta Wiese
    • Johannes Imhoff
  • • antimicrobial activities
    • bacterial cultures
    • chemical associations
    • Delesseria
    • epiphytic bacteria
    • Fucus
    • Kiel
    • macroalgabacteria associations

• Generalized class invariants with "Thetanullwerte"

  Uzunkol, O. (2013). Generalized class invariants with "Thetanullwerte". Turkish Journal of Mathematics, 37, 165–181. http://doi.org/10.3906/mat-1106-4

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    • Uzunkol, Osmanbey

  • Fachbereich

    • Fachbereich 3: Information und Kommunikation

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  • 2013
  • Journal Article
  • • Osmanbey Uzunkol

• A decision support framework for metrics selection in goal-based measurement programs: GQM-DSFMS

  Gencel, C., Petersen, K., Mughal, A. A., & Iqbal, M. I. (2013). A decision support framework for metrics selection in goal-based measurement programs: GQM-DSFMS. Journal of Systems and Software, 86, 3091–3108.

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    • Petersen, Kai

  • Abteilung/Einrichtung

    • FLAIR - Flensburg Artificial Intelligence Research

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  • 2013
  • Journal Article
  • • Cigdem Gencel
    • Kai Petersen
    • Aftab Mughal
    • Muhammad Iqbal