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2015

Nature s Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain

Kunz, A. L., Labes, A. ., Wiese, J. ., Bruhn, T. ., Bringmann, G. ., & Imhoff, J. F. (2015). Nature s Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain, Online-Ressource.
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2015

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Anna Kunz

Antje Labes

Jutta Wiese

Torsten Bruhn

Gerhard Bringmann

Johannes Imhoff
Low carbon supply chain configuration for a new product – a goal programming approach

Brandenburg, M. . (2015). Low carbon supply chain configuration for a new product – a goal programming approach. International Journal of Production Research, 53, 6588–6610. http://doi.org/10.1080/00207543.2015.1005761

Abstract

Green supply chain management and product innovation both have become sources of competitive advantage for companies from different industries. However, research on the configuration of green supply chains for new products represents a comparably new trend. In this paper, a goal programming approach is suggested to optimise the supply chain (SC) configuration for a new consumer product under consideration of economic and environmental criteria. The approach is illustrated by the case example of a fast moving consumer goods manufacturer. In this context, trade-offs between the ecologic factor of carbon emission, on the one hand, and financial value creation and customer service level on the other hand, are assessed in the deterministic analyses. The influence of long-term demand uncertainties is modelled in a scenario approach. It is observed that decentralised SC configurations enable carbon emission reduction without deteriorating the economic SC performance. Furthermore, it is detected that a focused economic optimisation strongly amplifies negative environmental impacts of demand uncertainties.
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Brandenburg, Marcus
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2015

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Marcus Brandenburg
Evaluation of simulation-assisted value stream mapping for software product development: Two industrial cases

Bin Ali, N. ., Petersen, K. ., & De Fran\cca, B. B. N. (2015). Evaluation of simulation-assisted value stream mapping for software product development: Two industrial cases. Information and Software Technology, 68, 45–61.
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Petersen, Kai

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FLAIR - Flensburg Artificial Intelligence Research
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2015

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Nauman Bin Ali

Kai Petersen

Breno De Fran\cca
Handover of managerial responsibilities in global software development: a case study of source code evolution and quality

Jabangwe, R. ., Börstler, J. ., & Petersen, K. . (2015). Handover of managerial responsibilities in global software development: a case study of source code evolution and quality. Software Quality Journal, 23, 539–566.
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Petersen, Kai

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FLAIR - Flensburg Artificial Intelligence Research
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2015

Journal Article

Ronald Jabangwe

Jürgen Börstler

Kai Petersen
Proteomic Analysis of Anti-Cancerous Scopularide Production by a Marine Microascus brevicaulis Strain and Its UV Mutant

Kramer, A. ., Beck, H. C., Kumar, A. ., Kristensen, L. P., Imhoff, J. F., & Labes, A. . (2015). Proteomic Analysis of Anti-Cancerous Scopularide Production by a Marine Microascus brevicaulis Strain and Its UV Mutant. PLoS ONE, 10, e0140047. Abgerufen von http://oceanrep.geomar.de/30275/

Abstract

The marine fungus Microascus brevicaulis strain LF580 is a non-model secondary metabolite producer with high yields of the two secondary metabolites scopularides A and B, which exhibit distinct activities against tumour cell lines. A mutant strain was obtained using UV mutagenesis, showing faster growth and differences in pellet formation besides higher production levels. Here, we show the first proteome study of a marine fungus. Comparative proteomics were applied to gain deeper understanding of the regulation of production and of the physiology of the wild type strain and its mutant. For this purpose, an optimised protein extraction protocol was established. In total, 4759 proteins were identified. The central metabolic pathway of strain LF580 was mapped using the KEGG pathway analysis and GO annotation. Employing iTRAQ labelling, 318 proteins were shown to be significantly regulated in the mutant strain: 189 were down- and 129 upregulated. Proteomics are a powerful tool for the understanding of regulatory aspects: The differences on proteome level could be attributed to limited nutrient availability in the wild type strain due to a strong pellet formation. This information can be applied for optimisation on strain and process level. The linkage between nutrient limitation and pellet formation in the non-model fungus M. brevicaulis is in consensus with the knowledge on model organisms like Aspergillus niger and Penicillium chrysogenum
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2015

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Annemarie Kramer

Hans Beck

Abhishek Kumar

Lars Kristensen

Johannes Imhoff

Antje Labes

Mutant strains

Proteomes

Protein extraction

Enzyme regulation

Fungi

Cell disruption

Protein metabolism

Biosynthesis
Prioritizing agile benefits and limitations in relation to practice usage

Solinski, A. ., & Petersen, K. . (2015). Prioritizing agile benefits and limitations in relation to practice usage. Software Quality Journal, 1–36.
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Petersen, Kai

Abteilung/Einrichtung

FLAIR - Flensburg Artificial Intelligence Research
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2015

Journal Article

Adam Solinski

Kai Petersen
More Efficient Secure Outsourcing Methods for Bilinear Maps

Arabacı, Öznur ., Kiraz, M. S., Sertkaya, İsa ., & Uzunkol, O. . (2015). More Efficient Secure Outsourcing Methods for Bilinear Maps. IACR Cryptol. EPrint Arch., 2015, 960. Abgerufen von http://eprint.iacr.org/2015/960
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Uzunkol, Osmanbey

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Fachbereich 3: Information und Kommunikation
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2015

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Öznur Arabacı

Mehmet Kiraz

İsa Sertkaya

Osmanbey Uzunkol
Die dänische Debatte über Priorisierung und Posteriorisierung in der Medizin – Was gibt es Neues?

Pornak, S. C., & Raspe, H. . (2015). Die dänische Debatte über Priorisierung und Posteriorisierung in der Medizin – Was gibt es Neues?. Das Gesundheitswesen, 77, e153–e159.
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Pornak, Shirin Caroline
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2015

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Shirin Pornak

Heiner Raspe
On rapid releases and software testing: a case study and a semi-systematic literature review

Mäntylä, M. . , V, Adams, B. ., Khomh, F. ., Engström, E. ., & Petersen, K. . (2015). On rapid releases and software testing: a case study and a semi-systematic literature review. Empirical Software Engineering, 20, 1384–1425.
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Petersen, Kai

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FLAIR - Flensburg Artificial Intelligence Research
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2015

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Mika Mäntylä V

Bram Adams

Foutse Khomh

Emelie Engström

Kai Petersen

2014

Power performance measurements of the NREL CART-2 wind turbine using a nacelle-based lidar scanner

Rettenmeier, A. ., Schlipf, D. ., Würth, I. ., & Cheng, P. W. (2014). Power performance measurements of the NREL CART-2 wind turbine using a nacelle-based lidar scanner. Journal of Atmospheric and Oceanic Technology, 31, 2029–2034. http://doi.org/10.1175/jtech-d-13-00154.1 (Original work published 2025)
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Schlipf, David
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2014

Journal Article

Andreas Rettenmeier

David Schlipf

Ines Würth

Po Cheng

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