Publikationen

2013

• A Safe Control Algorithm for Emulating Grid Inertia in Commercial Wind Turbines

  Geisler, J., & Schrader, S. (2013). A Safe Control Algorithm for Emulating Grid Inertia in Commercial Wind Turbines. In European Wind Energy Association Annual Conference and Exhibition 2013 (EWEA 2013). Wien. (Original work published Februar 2013)

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    • Geisler, Jens

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  • 2013
  • Conference Paper
  • • Jens Geisler
    • Stefan Schrader

• Worldviews, Research Methods, and their Relationship to Validity in Empirical Software Engineering Research

  Petersen, K., & Gencel, C. (2013). Worldviews, Research Methods, and their Relationship to Validity in Empirical Software Engineering Research. In The Joint Conference of the 23nd International Workshop on Software Measurement (IWSM) and the 8th International Conference on Software Process and Product Measurement (Mensura).

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    • Petersen, Kai

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    • FLAIR - Flensburg Artificial Intelligence Research

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  • Conference Paper
  • • Kai Petersen
    • Cigdem Gencel

• Random mutagenesis in filamentous fungi for higher yields of secondary metabolites

  Paun, L., Kramer, A., Labes, A., Imhoff, J. F., & Kempken, F. (2013). Random mutagenesis in filamentous fungi for higher yields of secondary metabolites. In 44. Annual Conference of the German Genetics Society (GfG). Abgerufen von http://oceanrep.geomar.de/22018/

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  • Conference Paper
  • • Linda Paun
    • Annemarie Kramer
    • Antje Labes
    • Johannes Imhoff
    • Frank Kempken

• Early drug discovery: Models for Entering Pharmaceutical Pipelines

  Labes, A. (2013). Early drug discovery: Models for Entering Pharmaceutical Pipelines. In 2. Deutsch-Russisches Forum Biotechnologie. Abgerufen von http://oceanrep.geomar.de/23001/

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  • Conference Paper
  • • Antje Labes

• Lean software development measures and indicators-a systematic mapping study

  Feyh, M., & Petersen, K. (2013). Lean software development measures and indicators-a systematic mapping study. In International Conference on Lean Enterprise Software and Systems (S. 32–47).

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    • Petersen, Kai

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    • FLAIR - Flensburg Artificial Intelligence Research

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  • Conference Paper
  • • Markus Feyh
    • Kai Petersen

• Genome based methods for the exploration of natural products from marine fungi for the treatment of cancer

  Labes, A. (2013). Genome based methods for the exploration of natural products from marine fungi for the treatment of cancer. In Tagung der Vereinigung für allgemeine und angewandte Mikrobiologie. Abgerufen von http://oceanrep.geomar.de/23000/

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  • • Antje Labes

• Habitat specific provocation of secondary metabolite production by marine bacteria ? microbial communication and pharmaceutical use

  Oesterwalbesloh, J., Wiese, J., Labes, A., & Imhoff, J. F. (2013). Habitat specific provocation of secondary metabolite production by marine bacteria ? microbial communication and pharmaceutical use. In VAAM Jahrestagung 2013. Abgerufen von http://oceanrep.geomar.de/20913/

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  • Conference Paper
  • • Jan Oesterwalbesloh
    • Jutta Wiese
    • Antje Labes
    • Johannes Imhoff

• Bio-mining the microbial treasures of the ocean: Early drug discovery and models for entering pharmaceutical pipelines

  Labes, A. (2013). Bio-mining the microbial treasures of the ocean: Early drug discovery and models for entering pharmaceutical pipelines. In SUBMARINER. Abgerufen von http://oceanrep.geomar.de/23002/

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  • • Antje Labes

• Towards Incorporating Sustainability while Taking Software Product Management Decisions

  Penzenstadler, B., Khurum, M., & Petersen, K. (2013). Towards Incorporating Sustainability while Taking Software Product Management Decisions. In 7th International Workshop on Software Product Management (S. 71–58).

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    • Petersen, Kai

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    • FLAIR - Flensburg Artificial Intelligence Research

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  • 2013
  • Conference Paper
  • • Birgit Penzenstadler
    • Mahvish Khurum
    • Kai Petersen

• Higher yields of cyclodepsipetides from Scopulariopsis brevicaulis by random mutagenesis

  Paun, L., Kramer, A., Hihlal, E., Labes, A., Imhoff, J. F., & Kempken, F. (2013). Higher yields of cyclodepsipetides from Scopulariopsis brevicaulis by random mutagenesis. In 27. Fungal Genetics Conference. Abgerufen von http://oceanrep.geomar.de/22016/

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  The ascomycete Scopulariopsis brevicaulis, which was isolated from the marine sponge Tethya aurantium, produces two cyclodepsipeptides, scopularides A and B [1]. Both peptides exhibit activity against several tumor cell lines. Within the EU-project MARINE FUNGI (EU FP7, 265926) one of our aims is to enhance the production of these secondary metabolites. We are in the process to establish two ways of random mutagenesis by both UV radiation and transposon-mediated. To this end we created UV-mutants and a miniaturised screening method was developed. UV-radiation was performed at 312 nm and the survival rate was set to 1 \%. With this method a mutant library was established. To screen these mutants for higher secondary metabolites production, we developed a miniaturised screening method which includes decreased cultivation volume, fast extraction and an optimised LC-MS analysis format. Using the UV mutagenesis, we were able to identify several mutants with a higher scopularide production in comparison to the wild type. One of these mutants, which produces three times more biomass and more than double the amount of scopularide A, has been used for another round of mutation. Next generation sequencing is being employed to identify the molecular genetic basis of the observed mutations. In parallel we employ transposable elements to introduce mutants [2]. The impact of transposons on gene expression as well as their ability to cause major mutations within the genome or single genes makes them an interesting tool for random mutagenesis [3, 4, 5]. We employ the Vader transposon in its homologous host and found that Vader mostly integrates within or very close to genes. Thus it appears to be a useful tool for transposon-mediated mutagenesis in A. niger (6). At current we try to enhance its usability by modifying the Vader element.

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  • 2013
  • Conference Paper
  • • Linda Paun
    • Annemarie Kramer
    • ElKbir Hihlal
    • Antje Labes
    • Johannes Imhoff
    • Frank Kempken