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2014

Reasons for bottlenecks in very large-scale system of systems development

Petersen, K. ., Khurum, M. ., & Angelis, L. . (2014). Reasons for bottlenecks in very large-scale system of systems development. Information and Software Technology, 56, 1403–1420.
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Petersen, Kai

Abteilung/Einrichtung

FLAIR - Flensburg Artificial Intelligence Research
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2014

Journal Article

Kai Petersen

Mahvish Khurum

Lefteris Angelis
A Simple Wind Model for Fast Wind Farm Simulations

Jauch, C. . (2014). A Simple Wind Model for Fast Wind Farm Simulations. WIND ENGINEERING, 38(5), 12.
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Jauch, Clemens
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2014

Journal Article

Prof. Dr. Clemens Jauch

WETI
A systematic literature review on the industrial use of software process simulation

Bin Ali, N. ., Petersen, K. ., & Wohlin, C. . (2014). A systematic literature review on the industrial use of software process simulation. Journal of Systems and Software, 97, 65–85.
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Petersen, Kai

Abteilung/Einrichtung

FLAIR - Flensburg Artificial Intelligence Research
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2014

Journal Article

Nauman Bin Ali

Kai Petersen

Claes Wohlin

2013

Model of the correlation between lidar systems and wind turbines for lidar-assisted control

Schlipf, D. ., Mann, J. ., & Cheng, P. W. (2013). Model of the correlation between lidar systems and wind turbines for lidar-assisted control. Journal of Atmospheric and Oceanic Technology, 30, 2233–2240. http://doi.org/10.1175/jtech-d-13-00077.1 (Original work published 2025)
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Schlipf, David
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2013

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David Schlipf

Jakob Mann

Po Cheng
Nonlinear model predictive control of wind turbines using LIDAR

Schlipf, D. ., Schlipf, D. J., & Kühn, M. . (2013). Nonlinear model predictive control of wind turbines using LIDAR. Wind Energy, 16, 1107–1129. http://doi.org/10.1002/we.1533 (Original work published 2025)
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Schlipf, David
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2013

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David Schlipf

Dominik Schlipf

Martin Kühn
Adaptive feedforward control for wind turbines

Schlipf, D. ., & Cheng, P. W. (2013). Adaptive feedforward control for wind turbines. at - Automatisierungstechnik, 61, 329–338. http://doi.org/10.1524/auto.2013.0029 (Original work published 2025)
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Schlipf, David
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2013

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David Schlipf

Po Cheng
$\ell_1$- optimal control of large wind turbines

Schuler, S. ., Schlipf, D. ., Cheng, P. W., & Allgöwer, F. . (2013). $\ell_1$- optimal control of large wind turbines. IEEE Transactions on Control Systems Technology, 21, 1079–1089. http://doi.org/10.1109/tcst.2013.2261068 (Original work published 2025)
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Schlipf, David
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2013

Journal Article

Simone Schuler

David Schlipf

Po Cheng

Frank Allgöwer
Calcarides A?E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain

Silber, J. ., Ohlendorf, B. ., Labes, A. ., Erhard, A. ., & Imhoff, J. F. (2013). Calcarides A?E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain. Marine Drugs, 11, 3309–3323. Abgerufen von http://oceanrep.geomar.de/21998/ (Original work published 2025)

Abstract

Bioactive compounds were detected in crude extracts of the fungus, Calcarisporium sp. KF525, which was isolated from German Wadden Sea water samples. Purification of the metabolites from the extracts yielded the five known polyesters, 15G256\ensuremath\alpha, \ensuremath\alpha-2, \ensuremath\beta, \ensuremath\beta-2 and \ensuremath\pi (1?5), and five new derivatives thereof, named calcarides A?E (6?10). The chemical structures of the isolated compounds were elucidated on the basis of one- and two-dimensional NMR spectroscopy supported by UV and HRESIMS data. The compounds exhibited inhibitory activities against Staphylococcus epidermidis, Xanthomonas campestris and Propionibacterium acnes. As the antibacterial activities were highly specific with regard to compound and test strain, a tight structure-activity relationship is assumed.
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2013

Journal Article

Johanna Silber

Birgit Ohlendorf

Antje Labes

Arlette Erhard

Johannes Imhoff

fungal natural products

Calcarisporium sp.

calcarides A?E

15G256 components

macrocyclic and linear polyesters

antibacterial activities

antibiotic

marine natural products
Integrated Therapy Safety Management System

Podtschaske, B. ., Fuchs, D. ., & Friesdorf, W. . (2013). Integrated Therapy Safety Management System. British Journal of Clinical Pharmacology, 76(Suppl 1), 5–13. http://doi.org/https://doi.org/10.1111/bcp.12155 (Original work published September 2013)

Abstract

The aim is to demonstrate the benefit of the medico-ergonomic approach for the redesign of clinical work systems. Based on the six layer model, a concept for an ‘integrated therapy safety management’ is drafted. This concept could serve as a basis to improve resilience. Methods The concept is developed through a concept-based approach. The state of the art of safety and complexity research in human factors and ergonomics forms the basis. The findings are synthesized to a concept for ‘integrated therapy safety management’. The concept is applied by way of example for the ‘medication process’ to demonstrate its practical implementation. Results The ‘integrated therapy safety management’ is drafted in accordance with the six layer model. This model supports a detailed description of specific work tasks, the corresponding responsibilities and related workflows at different layers by using the concept of ‘bridge managers’. ‘Bridge managers’ anticipate potential errors and monitor the controlled system continuously. If disruptions or disturbances occur, they respond with corrective actions which ensure that no harm results and they initiate preventive measures for future procedures. The concept demonstrates that in a complex work system, the human factor is the key element and final authority to cope with the residual complexity. The expertise of the ‘bridge managers’ and the recursive hierarchical structure results in highly adaptive clinical work systems and increases their resilience. Conclusions The medico-ergonomic approach is a highly promising way of coping with two complexities. It offers a systematic framework for comprehensive analyses of clinical work systems and promotes interdisciplinary collaboration.
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Podtschaske, Beatrice

Profilbereich

Gesundheit und Life Sciences

Fachbereich

Fachbereich 4: Wirtschaft
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2013

Journal Article

Beatrice Podtschaske

Daniela Fuchs

Wolfgang Friesdorf

six layer model

complexity

drug therapy

medico-ergonomic

resilience

workflow
Calcaripeptides A?C, Cyclodepsipeptides from a Calcarisporium Strain

Silber, J. ., Ohlendorf, B. ., Labes, A. ., Näther, C. ., & Imhoff, J. F. (2013). Calcaripeptides A?C, Cyclodepsipeptides from a Calcarisporium Strain. Journal of Natural Products, 76, 1461–1467. Abgerufen von http://oceanrep.geomar.de/21997/ (Original work published Juli 2013)

Abstract

The isolation and structure elucidation of the novel calcaripeptides A (1), B (2), and C (3) and studies on their biosynthetic origin are described. The calcaripeptides were identified from Calcarisporium sp. strain KF525, which was isolated from the German Wadden Sea. Compounds 1?3 are macrocyclic structures composed of a proline and a phenylalanine residue as well as a nonpeptidic substructure. Structure elucidation was achieved by applying one- and two-dimensional NMR spectroscopy supported by high-resolution mass spectrometry. X-ray crystallography was performed to determine the relative configuration of 1. The absolute configuration of 1 was assigned by HPLC of the amino acids after hydrolysis of the molecule and derivatization with chiral agents. Studies on the biosynthesis by feeding 13C-labeled substrates revealed that the nonpeptidic part of 1 originates from acetate and l-methionine. The involvement of a hybrid between a polyketide synthase and a nonribosomal peptide synthetase in the biosynthesis of the calcaripeptides is discussed.
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2013

Journal Article

Johanna Silber

Birgit Ohlendorf

Antje Labes

Christian Näther

Johannes Imhoff

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