Publikationen

2013

• Bio-mining the microbial treasures of the ocean: Early drug discovery and models for entering pharmaceutical pipelines

  Labes, A. . (2013). Bio-mining the microbial treasures of the ocean: Early drug discovery and models for entering pharmaceutical pipelines. In SUBMARINER. Abgerufen von http://oceanrep.geomar.de/23002/

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  • 2013
  • Conference Paper
  • • Antje Labes

• Phylogenetic analysis and antibiotic activity of bacteria isolated from the surface of two co-occurring macroalgae from the Baltic Sea

  Goecke, F. R., Labes, A. ., Wiese, J. ., & Imhoff, J. F. (2013). Phylogenetic analysis and antibiotic activity of bacteria isolated from the surface of two co-occurring macroalgae from the Baltic Sea. European Journal of Phycology, 48, 47–60. Abgerufen von http://oceanrep.geomar.de/19592/

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  Bacteria associated with Fucus vesiculosus and Delesseria sanguinea, two macroalgae from the Kiel Fjord were investigated seasonally over two years by cultivation-based methods. A total of 166 bacterial strains were isolated from the macroalgae, affiliated to seven classes of bacteria (Actinobacteria, Bacilli, Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Cytophagia and Flavobacteria). According to 16S rRNA gene sequence similarities they were arranged in 82 phylotypes of\ensuremath>99.0\% sequence identity. Assuming that chemical factors rule the bacteriamacroalga and bacteriabacteria interactions on algal surfaces, we tested the antibiotic activity of the bacterial isolates not only against a panel of four standard test organisms (Bacillus subtilis, Candida glabrata, Escherichia coli and Staphylococcus lentus) but also four macroalga-associated microorganisms: Algicola bacteriolytica and Pseudoalteromonas elyakovii (macroalgal pathogens), and Bacillus algicola and Formosa algae (strains associated with algal surfaces). Organic extracts of more than 51\% of the isolates from the two macroalgae inhibited the growth of at least one of the tested microorganisms. As much as 46\% and 45\% of the isolates derived from F. vesiculosus and D. sanguinea, respectively, showed antimicrobial activity against the set of macroalga-associated bacteria, compared with 13 and 19\% against a standard set of microorganisms. High antibacterial activity against macroalgal pathogens and bacterial competitors support the assumption that complex chemical interactions shape the relationships of bacteria associated with macroalgae and suggest that these bacteria are a rich source of antimicrobial metabolites.

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  • 2013
  • Journal Article
  • • Franz Goecke
    • Antje Labes
    • Jutta Wiese
    • Johannes Imhoff
  • • antimicrobial activities
    • bacterial cultures
    • chemical associations
    • Delesseria
    • epiphytic bacteria
    • Fucus
    • Kiel
    • macroalgabacteria associations

• Visualization of Defect Inflow and Resolution Cycles: Before, During and After Transfer

  Jabangwe, R. ., Petersen, K. ., & vSmite, D. \. (2013). Visualization of Defect Inflow and Resolution Cycles: Before, During and After Transfer. In 20th Asia-Pacific Software Engineering Conference.

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    • Petersen, Kai

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    • FLAIR - Flensburg Artificial Intelligence Research

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  • 2013
  • Conference Paper
  • • Ronald Jabangwe
    • Kai Petersen
    • Darja vSmite

• Higher yields of cyclodepsipetides from Scopulariopsis brevicaulis by random mutagenesis

  Paun, L. ., Kramer, A. ., Hihlal, E. ., Labes, A. ., Imhoff, J. F., & Kempken, F. . (2013). Higher yields of cyclodepsipetides from Scopulariopsis brevicaulis by random mutagenesis. In 27. Fungal Genetics Conference. Abgerufen von http://oceanrep.geomar.de/22016/

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  The ascomycete Scopulariopsis brevicaulis, which was isolated from the marine sponge Tethya aurantium, produces two cyclodepsipeptides, scopularides A and B [1]. Both peptides exhibit activity against several tumor cell lines. Within the EU-project MARINE FUNGI (EU FP7, 265926) one of our aims is to enhance the production of these secondary metabolites. We are in the process to establish two ways of random mutagenesis by both UV radiation and transposon-mediated. To this end we created UV-mutants and a miniaturised screening method was developed. UV-radiation was performed at 312 nm and the survival rate was set to 1 \%. With this method a mutant library was established. To screen these mutants for higher secondary metabolites production, we developed a miniaturised screening method which includes decreased cultivation volume, fast extraction and an optimised LC-MS analysis format. Using the UV mutagenesis, we were able to identify several mutants with a higher scopularide production in comparison to the wild type. One of these mutants, which produces three times more biomass and more than double the amount of scopularide A, has been used for another round of mutation. Next generation sequencing is being employed to identify the molecular genetic basis of the observed mutations. In parallel we employ transposable elements to introduce mutants [2]. The impact of transposons on gene expression as well as their ability to cause major mutations within the genome or single genes makes them an interesting tool for random mutagenesis [3, 4, 5]. We employ the Vader transposon in its homologous host and found that Vader mostly integrates within or very close to genes. Thus it appears to be a useful tool for transposon-mediated mutagenesis in A. niger (6). At current we try to enhance its usability by modifying the Vader element.

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  • 2013
  • Conference Paper
  • • Linda Paun
    • Annemarie Kramer
    • ElKbir Hihlal
    • Antje Labes
    • Johannes Imhoff
    • Frank Kempken

• C++ Der Einstieg

  Willemer, A. . (2013). C++ Der Einstieg (S. 536). Weinheim: Wiley-VCH.

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    • Willemer, Arnold

  • Fachbereich

    • Fachbereich 3: Information und Kommunikation

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  • 2013
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  • • Arnold Willemer

• Das Meer erforschen und Medizin finden

  Labes, A. . (2013). Das Meer erforschen und Medizin finden. In Zukunft Meer - Ein Abend über das Erforschen, die Nutzung und den Schutz der Meere. Abgerufen von http://oceanrep.geomar.de/23010/

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  • • Antje Labes

• Improving software security with static automated code analysis in an industry setting

  Baca, D. ., Carlsson, B. ., Petersen, K. ., & Lundberg, L. . (2013). Improving software security with static automated code analysis in an industry setting. Software: Practice and Experience, 43, 259–279.

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    • Petersen, Kai

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    • FLAIR - Flensburg Artificial Intelligence Research

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  • 2013
  • Journal Article
  • • Dejan Baca
    • Bengt Carlsson
    • Kai Petersen
    • Lars Lundberg

• Worldviews, Research Methods, and their Relationship to Validity in Empirical Software Engineering Research

  Petersen, K. ., & Gencel, C. . (2013). Worldviews, Research Methods, and their Relationship to Validity in Empirical Software Engineering Research. In The Joint Conference of the 23nd International Workshop on Software Measurement (IWSM) and the 8th International Conference on Software Process and Product Measurement (Mensura).

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    • Petersen, Kai

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    • FLAIR - Flensburg Artificial Intelligence Research

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  • 2013
  • Conference Paper
  • • Kai Petersen
    • Cigdem Gencel

• Marine Biotechnologie in Schleswig-Holstein für die Apotheke aus dem Meer Technologietransfer für die Wirkstoffsuche aus marinen mikrobiellen Ressourcen

  Labes, A. . (2013). Marine Biotechnologie in Schleswig-Holstein für die Apotheke aus dem Meer Technologietransfer für die Wirkstoffsuche aus marinen mikrobiellen Ressourcen. In Innovation Camp der FH Kiel. Abgerufen von http://oceanrep.geomar.de/23007/

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  • • Antje Labes

• A Semantics for Weakly Encapsulated Search in Functional Logic Programs

  Christiansen, J. ., Hanus, M. ., Reck, F. ., & Seidel, D. . (2013). A Semantics for Weakly Encapsulated Search in Functional Logic Programs. In Proceedings of the 15th Symposium on Principles and Practice of Declarative Programming - PPDP 13 (S. 49–60). ACM Press. http://doi.org/10.1145/2505879.2505896

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  Encapsulated search is a key feature of (functional) logic languages. It allows the programmer to access and process different results of a non-deterministic computation within a program. Unfortunately, due to advanced operational features (lazy evaluation, partial values, infinite structures), there is no straightforward definition of the semantics of encapsulated search in functional logic languages. As a consequence, various proposals and implementations are available but a rigorous definition covering all semantical aspects does not exist. In this paper, we analyze the requirements of encapsulated search in a functional logic language like Curry and provide a comprehensive definition that covers weak encapsulation, a modular form of encapsulation, as well as nested applications of search operators. We set up a denotational semantics that distinguishes non-termination and different levels of failures in a computation. The semantics is also the basis of a practical implementation of search operators in the functional logic language Curry.

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    • Christiansen, Jan

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    • Fachbereich 3: Information und Kommunikation

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  • 2013
  • Conference Paper
  • • Jan Christiansen
    • Michael Hanus
    • Fabian Reck
    • Daniel Seidel