Publikationen

2013

• Calcarides A?E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain

  Silber, J. ., Ohlendorf, B. ., Labes, A. ., Erhard, A. ., & Imhoff, J. F. (2013). Calcarides A?E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain. Marine Drugs, 11, 3309–3323. Abgerufen von http://oceanrep.geomar.de/21998/ (Original work published 2024)

  Abstract

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  Bioactive compounds were detected in crude extracts of the fungus, Calcarisporium sp. KF525, which was isolated from German Wadden Sea water samples. Purification of the metabolites from the extracts yielded the five known polyesters, 15G256\ensuremath\alpha, \ensuremath\alpha-2, \ensuremath\beta, \ensuremath\beta-2 and \ensuremath\pi (1?5), and five new derivatives thereof, named calcarides A?E (6?10). The chemical structures of the isolated compounds were elucidated on the basis of one- and two-dimensional NMR spectroscopy supported by UV and HRESIMS data. The compounds exhibited inhibitory activities against Staphylococcus epidermidis, Xanthomonas campestris and Propionibacterium acnes. As the antibacterial activities were highly specific with regard to compound and test strain, a tight structure-activity relationship is assumed.

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  • 2013
  • Journal Article
  • • Johanna Silber
    • Birgit Ohlendorf
    • Antje Labes
    • Arlette Erhard
    • Johannes Imhoff
  • • fungal natural products
    • Calcarisporium sp.
    • calcarides A?E
    • 15G256 components
    • macrocyclic and linear polyesters
    • antibacterial activities
    • antibiotic
    • marine natural products