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2012

Bio-mining the microbial treasures of the ocean. Early drug discovery and models for entering pharmaceutical pipelines

Labes, A. . (2012). Bio-mining the microbial treasures of the ocean. Early drug discovery and models for entering pharmaceutical pipelines. In Rende-vouz de Concarneau. Abgerufen von http://oceanrep.geomar.de/15366/
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2012

Conference Paper

Antje Labes
The Second Skin: Ecological Role of Epibiotic Biofilms on Marine Organisms

Wahl, M. ., Goecke, F. R., Labes, A. ., Dobretsov, S. ., & Weinberger, F. . (2012). The Second Skin: Ecological Role of Epibiotic Biofilms on Marine Organisms. Frontiers in Microbiology, 3, 292. Abgerufen von http://oceanrep.geomar.de/15124/

Abstract

In the aquatic environment, biofilms on solid surfaces are omnipresent. The outer body surface of marine organisms often represents a highly active interface between host and biofilm. Since biofilms on living surfaces have the capacity to affect the fluxes of information, energy, and matter across the host?s body surface, they have an important ecological potential to modulate the abiotic and biotic interactions of the host. Here we review existing evidence how marine epibiotic biofilms affect their hosts? ecology by altering the properties of and processes across its outer surfaces. Biofilms have a huge potential to reduce its host?s access to light, gases, and/or nutrients and modulate the host?s interaction with further foulers, consumers, or pathogens. These effects of epibiotic biofilms may intensely interact with environmental conditions. The quality of a biofilm?s impact on the host may vary from detrimental to beneficial according to the identity of the epibiotic partners, the type of interaction considered, and prevailing environmental conditions. The review concludes with some unresolved but important questions and future perspectives.
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2012

Journal Article

Martin Wahl

Franz Goecke

Antje Labes

Sergey Dobretsov

Florian Weinberger

Stress

microbe-macroorganism interaction

modulation of interactions

epibiosis

chemical ecology

biofilm
Meer Kosmetik. Neue Rohstoffe und Kosmetikkonzepte aus dem Meer ? was können marine mikrobielle Ressourcen dazu beitragen?

Labes, A. . (2012). Meer Kosmetik. Neue Rohstoffe und Kosmetikkonzepte aus dem Meer ? was können marine mikrobielle Ressourcen dazu beitragen?. In L Oreal Pressekonferenz. Abgerufen von http://oceanrep.geomar.de/15352/
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2012

Conference Paper

Antje Labes
Bioactive products of marine microorganisms ? from biological interactions to application in an Europoean framework

Imhoff, J. F., & Labes, A. . (2012). Bioactive products of marine microorganisms ? from biological interactions to application in an Europoean framework. In Meeting of the Scientific Advisory Board - GEOMAR. Abgerufen von http://oceanrep.geomar.de/19552/
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2012

Conference Paper

Johannes Imhoff

Antje Labes
Wenn sich Bakterien unterhalten ? Bakterielle Interaktionen (im Meer)

Labes, A. . (2012). Wenn sich Bakterien unterhalten ? Bakterielle Interaktionen (im Meer). In 2. LifeScience Conference Analytik Jena. Abgerufen von http://oceanrep.geomar.de/15363/
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2012

Conference Paper

Antje Labes

2011

Neo-Nature ? die neue Naturkosmetik

Labes, A. . (2011). Neo-Nature ? die neue Naturkosmetik. In Beauty Düsseldorf. Abgerufen von http://oceanrep.geomar.de/15233/
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2011

Conference Paper

Antje Labes

natural cosmetics
Bacteria associated with coexisting macroalgae: seasonal, interspecies variation and antibiotic effects

Goecke, F. R., Labes, A. ., Wiese, J. ., & Imhoff, J. F. (2011). Bacteria associated with coexisting macroalgae: seasonal, interspecies variation and antibiotic effects. In VAAM-Jahrestagung 2011. Abgerufen von http://oceanrep.geomar.de/12920/
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2011

Conference Paper

Franz Goecke

Antje Labes

Jutta Wiese

Johannes Imhoff

Microbiology

Medical Science

BACTERIA

antibiotic effects

Macroalgae
Neue chemische Wertstoffe mit Enzymen aus marinen Organismen

Labes, A. . (2011). Neue chemische Wertstoffe mit Enzymen aus marinen Organismen. In IBN-Forum. Abgerufen von http://oceanrep.geomar.de/14305/
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2011

Conference Paper

Antje Labes

Microbiology
Bio-mining the microbial treasures of the ocean: New natural products

Imhoff, J. F., Labes, A. ., & Wiese, J. . (2011). Bio-mining the microbial treasures of the ocean: New natural products. Biotechnology Advances, 29, 468–482. Abgerufen von http://oceanrep.geomar.de/12044/

Abstract

The biological resources of the oceans have been exploited since ancient human history, mainly by catching fish and harvesting algae. Research on natural products with special emphasis on marine animals and also algae during the last decades of the 20th century has revealed the importance of marine organisms as producers of substances useful for the treatment of human diseases. Though a large number of bioactive substances have been identified, some many years ago, only recently the first drugs from the oceans were approved. Quite astonishingly, the immense diversity of microbes in the marine environments and their almost untouched capacity to produce natural products and therefore the importance of microbes for marine biotechnology was realized on a broad basis by the scientific communities only recently. This has strengthened worldwide research activities dealing with the exploration of marine microorganisms for biotechnological applications, which comprise the production of bioactive compounds for pharmaceutical use, as well as the development of other valuable products, such as enzymes, nutraceuticals and cosmetics. While the focus in these fields was mainly on marine bacteria, also marine fungi now receive growing attention. Although culture-dependent studies continue to provide interesting new chemical structures with biological activities at a high rate and represent highly promising approaches for the search of new drugs, exploration and use of genomic and metagenomic resources are considered to further increase this potential. Many efforts are made for the sustainable exploration of marine microbial resources. Large culture collections specifically of marine bacteria and marine fungi are available. Compound libraries of marine natural products, even of highly purified substances, were established. The expectations into the commercial exploitation of marine microbial resources has given rise to numerous institutions worldwide, basic research facilities as well as companies. In Europe, recent activities have initiated a dynamic development in marine biotechnology, though concentrated efforts on marine natural product research are rare. One of these activities is represented by the Kieler Wirkstoff-Zentrum KiWiZ, which was founded in 2005 in Kiel (Germany).
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2011

Journal Article

Johannes Imhoff

Antje Labes

Jutta Wiese

Microbiology

Marine bacteria

marine fungi

Bioassays

natural products

Microbial interactions

Compound library

Strain collection

Marine biotechnology in Europe

Genetic resources
Secondary metabolites of fungi associated to the marine sponge Halichondria panacea

Kramer, A. ., Labes, A. ., Wiese, J. ., Ohlendorf, B. ., & Imhoff, J. F. (2011). Secondary metabolites of fungi associated to the marine sponge Halichondria panacea. In MIMAS Symposium. Abgerufen von http://oceanrep.geomar.de/12918/
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2011

Conference Paper

Annemarie Kramer

Antje Labes

Jutta Wiese

Birgit Ohlendorf

Johannes Imhoff

Microbiology

marine sponge Halichondria panacea

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