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2010

Schätze aus dem Ozean: Neue Naturstoffe aus marinen Mikroorganismen und ihrer Interaktion mit der Umwelt

Wiese, J. ., & Labes, A. . (2010). Schätze aus dem Ozean: Neue Naturstoffe aus marinen Mikroorganismen und ihrer Interaktion mit der Umwelt. In Enterprise Europe Network: EU Workshop 2010. Abgerufen von http://oceanrep.geomar.de/10225/
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2010

Conference Paper

Jutta Wiese

Antje Labes

Microbiology

natural products

marine microorganism
Comprehensive Investigation of Marine Actinobacteria Associated with the Sponge Halichondria panicea

Schneemann, I. ., Nagel, K. ., Kajahn, I. ., Labes, A. ., Wiese, J. ., & Imhoff, J. F. (2010). Comprehensive Investigation of Marine Actinobacteria Associated with the Sponge Halichondria panicea. Applied and Environmental Microbiology, 76, 3702–3714. Abgerufen von http://oceanrep.geomar.de/8488/

Abstract

Representatives of Actinobacteria were isolated from the marine sponge Halichondria panicea collected from the Baltic Sea (Germany). For the first time, a comprehensive investigation was performed with regard to phylogenetic strain identification, secondary metabolite profiling, bioactivity determination, and genetic exploration of biosynthetic genes, especially concerning the relationships of the abundance of biosynthesis gene fragments to the number and diversity of produced secondary metabolites. All strains were phylogenetically identified by 16S rRNA gene sequence analyses and were found to belong to the genera Actinoalloteichus, Micrococcus, Micromonospora, Nocardiopsis, and Streptomyces. Secondary metabolite profiles of 46 actinobacterial strains were evaluated, 122 different substances were identified, and 88 so far unidentified compounds were detected. The extracts from most of the cultures showed biological activities. In addition, the presence of biosynthesis genes encoding polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) in 30 strains was established. It was shown that strains in which either PKS or NRPS genes were identified produced a significantly higher number of metabolites and exhibited a larger number of unidentified, possibly new metabolites than other strains. Therefore, the presence of PKS and NRPS genes is a good indicator for the selection of strains to isolate new natural products.
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2010

Journal Article

Imke Schneemann

Kerstin Nagel

Inga Kajahn

Antje Labes

Jutta Wiese

Johannes Imhoff

Microbiology

Biology

BIOSYNTHESIS GENE-CLUSTER

COMPLETE GENOME SEQUENCE

STREPTOMYCES SP

BIOLOGICAL PROPERTIES

POLYKETIDE SYNTHASE

NATURAL-PRODUCTS

PSEUDOCERATINA-CLAVATA

ANTIMYCIN ANTIBIOTICS

STRUCTURE ELUCIDATION

CHONDRILLA-NUCULA

2009

Ecological impact of biologically active metabolites produced by Laminaria Saccharina associated Pseudomonas Sp. Strains

Nagel, K. ., Schneemann, I. ., Wiese, J. ., Kajahn, I. ., Labes, A. ., & Imhoff, J. F. (2009). Ecological impact of biologically active metabolites produced by Laminaria Saccharina associated Pseudomonas Sp. Strains. 6th European Conference on Marine Natural Products. Abgerufen von http://oceanrep.geomar.de/5526/
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2009

Unpublished

Kerstin Nagel

Imke Schneemann

Jutta Wiese

Inga Kajahn

Antje Labes

Johannes Imhoff

Poster
Marine streptomycetes as source for new natural products

Schulz, D. ., Mitova, M. ., Schneemann, I. ., Kajahn, I. ., Labes, A. ., Lang, G. ., … Imhoff, J. F. (2009). Marine streptomycetes as source for new natural products. Biology of Streptomycetes. Abgerufen von http://oceanrep.geomar.de/196/
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2009

Unpublished

Dirk Schulz

M. Mitova

I. Schneemann

Inga Kajahn

Antje Labes

G. Lang

Vera Thiel

Jutta Wiese

Johannes Imhoff

Poster
Variability of the algae-associated bacterial communities among coexisting Fucus vesiculosus (Phaephyceae) and Delesseria sanguinea (Rhodophyta) in the Baltic Sea

Goecke, F. R., Wiese, J. ., Labes, A. ., & Imhoff, J. F. (2009). Variability of the algae-associated bacterial communities among coexisting Fucus vesiculosus (Phaephyceae) and Delesseria sanguinea (Rhodophyta) in the Baltic Sea. VAAM Jahrestagung. Abgerufen von http://oceanrep.geomar.de/2324/
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2009

Unpublished

Franz Goecke

Jutta Wiese

Antje Labes

Johannes Imhoff

Poster
Biological role of secondary metabolites from marine microorganisms

Baumann, H. I., Wiese, J. ., Gärtner, A. ., Goecke, F. R., Heindl, H. ., Kajahn, I. ., … Imhoff, J. F. (2009). Biological role of secondary metabolites from marine microorganisms. VAAM-Symposium "Symbiotische Interaktionen". Abgerufen von http://oceanrep.geomar.de/3859/
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2009

Unpublished

Heike Baumann

Jutta Wiese

Andrea Gärtner

Franz Goecke

Herwig Heindl

Inga Kajahn

Katrin Kleinschmidt

Antje Labes

Kerstin Nagel

Sven Neulinger

Birgit Ohlendorf

Imke Schneemann

Dirk Schulz

Tim Staufenberger

Vera Thiel

Heidi Zinecker

Johannes Imhoff

2008

New natural products from marine microorganisms

Labes, A. ., Kajahn, I. ., Krämer, M. ., Stöhr, R. ., Thiel, V. ., Wiese, J. ., & Imhoff, J. F. (2008). New natural products from marine microorganisms. European Bioperspectives. Abgerufen von http://oceanrep.geomar.de/6849/
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2008

Unpublished

Antje Labes

Inga Kajahn

Marco Krämer

Rüdiger Stöhr

Vera Thiel

Jutta Wiese

Johannes Imhoff

Poster
Exploiting the pharmaceutical potential of Marine Microorganisms

Gärtner, A. ., Krämer, M. ., Kajahn, I. ., Labes, A. ., Nagel, K. ., Stöhr, R. ., … Imhoff, J. F. (2008). Exploiting the pharmaceutical potential of Marine Microorganisms. XXX. Congreso Chileno de Microbiolog\ ia. Abgerufen von http://oceanrep.geomar.de/6763/
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2008

Unpublished

Andrea Gärtner

Marco Krämer

Inga Kajahn

Antje Labes

Kerstin Nagel

Rüdiger Stöhr

Rolf Schmaljohann

Imke Schneemann

Vera Thiel

Jutta Wiese

Johannes Imhoff

Poster
Marine Microbial Resources

Wiese, J. ., Gärtner, A. ., Heindl, H. ., Kajahn, I. ., Krämer, M. ., Labes, A. ., … Imhoff, J. F. (2008). Marine Microbial Resources. 2. Bi-Annual Symposium "The Future Ocean". Abgerufen von http://oceanrep.geomar.de/6631/
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2008

Unpublished

Jutta Wiese

Andrea Gärtner

Herwig Heindl

Inga Kajahn

Marco Krämer

Antje Labes

Gerhard Lang

M. Mitova

Kerstin Nagel

Rolf Schmaljohann

Imke Schneemann

Rüdiger Stöhr

Vera Thiel

Z. Ju

Johannes Imhoff

Poster
Marine biotechnology: bio-mining the treasures of the ocean

Imhoff, J. F., Labes, A. ., Kajahn, I. ., Krämer, M. ., Stöhr, R. ., Thiel, V. ., & Wiese, J. . (2008). Marine biotechnology: bio-mining the treasures of the ocean. European Bioperspectives. Abgerufen von http://oceanrep.geomar.de/6415/
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2008

Unpublished

Johannes Imhoff

Antje Labes

Inga Kajahn

Marco Krämer

Rüdiger Stöhr

Vera Thiel

Jutta Wiese

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