@article{931, keywords = {MRSA, antibiotic, lindgomycin, marine fungi, marine natural products}, author = {Bin Wu and Jutta Wiese and Antje Labes and Annemarie Kramer and Rolf Schmaljohann and Johannes Imhoff}, title = {Lindgomycin, an Unusual Antibiotic Polyketide from a Marine Fungus of the Lindgomycetaceae}, abstract = {

An unusual polyketide with a new carbon skeleton, lindgomycin (1), and the recently described ascosetin (2) were extracted from mycelia and culture broth of different Lindgomycetaceae strains, which were isolated from a sponge of the Kiel Fjord in the Baltic Sea (Germany) and from the Antarctic. Their structures were established by spectroscopic means. In the new polyketide, two distinct domains, a bicyclic hydrocarbon and a tetramic acid, are connected by a bridging carbonyl. The tetramic acid substructure of compound 1 was proved to possess a unique 5-benzylpyrrolidine-2,4-dione unit. The combination of 5-benzylpyrrolidine-2,4-dione of compound 1 in its tetramic acid half and 3-methylbut-3-enoic acid pendant in its decalin half allow the assignment of a new carbon skeleton. The new compound 1 and ascosetin showed antibiotic activities with IC50 value of 5.1 ($\pm$0.2) ?M and 3.2 ($\pm$0.4) \ensuremath\muM, respectively, against methicillin-resistant Staphylococcus aureus.

}, year = {2015}, booktitle = {Marine Drugs}, journal = {Marine Drugs}, volume = {13}, number = {8}, pages = {4617-4632}, url = {http://oceanrep.geomar.de/29518/}, note = {In Pangaea wird hinterlegt: Spektren : K504Lutz\_2174 (MeOD) (April 2012) ; K510Lutz\_4429 (Aceton-d6) ; (Okt. 2012) WOS:000360625700003}, }